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Metoder för att upptäcka alternativa Promoter Användning och transkriptionsreglering av murin Bcrp1
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Metoder för att upptäcka alternativa Promoter Användning och transkriptionsreglering av murin Bcrp1

Article DOI: 10.3791/53827-v • 11:02 min • May 27th, 2016
May 27th, 2016 •
1,2, 1,3, 4, 5,6, 7, 1,3,8,9, 1,3,8,9,10,11
1Greenebaum Cancer Center, University of Maryland School of Medicine, 2Pharmaceutical Sciences, University of Maryland School of Pharmacy, 3Baltimore VA Medical Center, 4Membrane Transport and Biopharmaceutics, School of Pharmaceutical Sciences, Kanazawa University, 5Obstetrics, Gynecology and Reproductive Science, University of Pittsburgh, 6Magee Women's Research Institute, 7Obstetrics, Gynecology, Perinatal Research Branch (NICHD), Wayne State University School of Medicine, 8Medicine, University of Maryland School of Medicine, 9Pathology, University of Maryland School of Medicine, 10Pharmacology, University of Maryland School of Medicine, 11Experimental Therapeutics, University of Maryland School of Medicine

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Med mus ABC-transport Bcrp1 (ABCG2) som ett exempel, in silico-protokoll presenteras för att upptäcka alternativa promotor användning i gener som uttrycks i mus vävnader, och att utvärdera funktionaliteten av de alternativa promotorer identifieras med hjälp av reporteranalyser.

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Medicin Promoter Bcrp1 alternativa promotoranvändning E1U mus testiklar steroidogena faktor-1
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