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Journal / Neuroscience / 在转基因小鼠神经炎症的生物发光成像的α-共核蛋白纤丝的外围接种后…
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Neuroscience

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JoVE Journal Neuroscience
在转基因小鼠神经炎症的生物发光成像的α-共核蛋白纤丝的外围接种后
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在转基因小鼠神经炎症的生物发光成像的α-共核蛋白纤丝的外围接种后

Article DOI: 10.3791/55503-v • 09:32 min • April 13th, 2017
April 13th, 2017 •
1, 1, 1, 2, 2, 1
1German Center for Neurodegenerative Diseases (DZNE), 2Centre for Prions and Protein Folding Diseases & Department of Biochemistry, University of Alberta

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外周注射的α-突触核蛋白原纤维进入的Tg的腹膜或舌的（M83 +/-：GFAP -luc +/-）小鼠，表达人α-突触核蛋白与家族性A53T突变和萤火虫萤光素酶，可诱发神经病理学，包括神经炎症在他们的中枢神经系统。

Tags

神经科学，第122，α-突触核蛋白，生物发光成像，炎症，共核蛋白病，神经侵染，帕金森氏病，外周，朊病毒等，prionoid
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