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Journal / Neuroscience / 矩阵辅助激光去离子成像质谱法显示人脑中的淀粉样β矿床…
JoVE Journal
Neuroscience

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JoVE Journal Neuroscience
矩阵辅助激光去离子成像质谱法显示人脑中的淀粉样β矿床
High-resolution Functional Magnetic Resonance Imaging Methods for Human Midbrain
Journal (Neuroscience)
High-resolution Functional Magnetic Resonance Imaging Methods for Human Midbrain
Recording Large-scale Neuronal Ensembles with Silicon Probes in the Anesthetized Rat
Journal (Neuroscience)
Recording Large-scale Neuronal Ensembles with Silicon Probes in the Anesthetized Rat
 
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矩阵辅助激光去离子成像质谱法显示人脑中的淀粉样β矿床

Article DOI: 10.3791/57645-v • 09:31 min • March 7th, 2019
March 7th, 2019 •
*1, *2, 1, 1, 1, 3, 4
1Department of Life and Medical Systems, Doshisha University, 2Bruker Daltonics K.K., 3The Brain Bank for Aging Research, Tokyo Metropolitan Geriatric Hospital and Institute of Gerontology, 4Graduate School of Brain Science, Doshisha University
* These authors contributed equally

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分子成像与矩阵辅助激光脱盐/电离成像质谱 (caldi-ims) 允许同时映射多个分析物的生物样本。在这里, 我们提出了一个协议, 检测和可视化在脑组织上的淀粉样β蛋白阿尔茨海默氏病和脑淀粉样血管病变样本使用 maldi-ims。

Tags

神经科学 第14期 maldi 成像质谱 人体尸检大脑 淀粉样β 阿尔茨海默病 老年斑块 脑淀粉样血管病变
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