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JoVE Journal Chemistry
Syntese og struktur bestemmelse af µ-Conotoxin PIIIA isomerer med forskellige disulfid Connectivities
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Syntese og struktur bestemmelse af µ-Conotoxin PIIIA isomerer med forskellige disulfid Connectivities

Article DOI: 10.3791/58368-v • 11:44 min • October 2nd, 2018
October 2nd, 2018 •
*1, *1, *1, 1
1Pharmaceutical Biochemistry and Bioanalytics, Pharmaceutical Institute, University of Bonn
* These authors contributed equally

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Cystein-rige peptider fold i særskilte tredimensionale strukturer afhængigt af deres disulfid connectivity. Målrettet syntese af individuelle disulfid isomerer er påkrævet, når buffer oxidation ikke fører til den ønskede disulfid connectivity. Protokollen beskæftiger sig med den selektive syntese af 3-disulfid-bonded peptider og deres strukturelle analyse ved hjælp af NMR- og MS/MS undersøgelser.

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Kemi spørgsmål 140 peptider cystein-rige disulfid connectivity syntese beskytte gruppe strategi struktur analyse 2D NMR (nuclear magnetic resonance) MS/MS (tandem massespektrometri)
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