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Cancer Research

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JoVE Journal Cancer Research
Ressonância de superfície melhorada Raman dispersão nano-sonda Ratiometry para detecção de câncer de ovário microscópico através do Receptor de folato como alvo
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Ressonância de superfície melhorada Raman dispersão nano-sonda Ratiometry para detecção de câncer de ovário microscópico através do Receptor de folato como alvo

Article DOI: 10.3791/58389-v • 07:54 min • March 25th, 2019
March 25th, 2019 •
1, 1, 1, 1,2, 1, 1,3,4,5,6,7
1Department of Radiology, Memorial Sloan Kettering Cancer Center, 2Department of Chemistry, The Graduate Center of the City University of New York, 3Molecular Pharmacology Program, Memorial Sloan Kettering Cancer Center, 4Center for Molecular Imaging and Nanotechnology (CMINT), Memorial Sloan Kettering Cancer Center, 5Gerstner Sloan Kettering Graduate School of Biomedical Sciences, 6Department of Radiology, Weill Cornell Medical College of Cornell University, 7Dana-Farber Cancer Institute and Harvard Medical Center

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Câncer de ovário forma metástases em toda a cavidade peritoneal. Aqui, apresentamos um protocolo para fazer e uso folato receptores alvo superfície melhorada ressonância nanosondas de espalhamento Raman que revelam estas lesões com alta especificidade através de ratiometric de imagem. As nanosondas são administradas intraperitonealmente com ratos vivos, e as imagens derivadas se correlacionam bem com a histologia.

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Pesquisa sobre o câncer edição 145 Raman SERS nanopartículas imagem molecular câncer de ovário receptor de folato ratiometry
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