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Journal / Biochemistry / 大鼠甲基 Seq…
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Biochemistry

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JoVE Journal Biochemistry
大鼠甲基 Seq 平台识别与应力接触相关的表观变化
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大鼠甲基 Seq 平台识别与应力接触相关的表观变化

Article DOI: 10.3791/58617-v • 09:06 min • October 24th, 2018
October 24th, 2018 •
1, 1, 1, 1, 1, 1,3, 1,2, 1
1Departments of Psychiatry and Behavioral Sciences, Johns Hopkins School of Medicine, 2Department of Medicine, Johns Hopkins School of Medicine, 3Department of Mental Health, Johns Hopkins School of Public Health

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在这里, 我们描述了同道平台甲基 Seq 的协议和实现, 使用老鼠模型来识别与慢性应力暴露相关的表观变化。结果表明, 大鼠甲基序列平台能够检测大鼠应力暴露引起的甲基化差异。

Tags

生物化学 问题 140 表观遗传学 DNA 甲基化 大鼠 甲基序列 应力 神经内分泌学
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