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JoVE Journal Medicine
Tracking superparamagnetisk jernoxid-mærket Mesenchymal stamceller ved hjælp af MRI efter intranasal levering i en traumatisk hjerneskade murine model
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Tracking superparamagnetisk jernoxid-mærket Mesenchymal stamceller ved hjælp af MRI efter intranasal levering i en traumatisk hjerneskade murine model

Article DOI: 10.3791/60450-v • 10:03 min • November 21st, 2019
November 21st, 2019 •
1,2,3, 2,3,4,5, 1,2,3,4,5, 1,2,3
1Ph.D. Program for Neural Regenerative Medicine, College of Medical Science and Technology, Taipei Medical University and National Health Research Institutes, 2Center for Neurotrauma and Neuroregeneration, Taipei Medical University, 3TMU Neuroscience Research Center, Taipei Medical University, 4Department of Neurosurgery, Taipei Medical University Hospital, 5Department of Surgery, School of Medicine, College of Medicine, Taipei Medical University

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Præsenteret her er en protokol for ikke-invasiv mesenchymal stamcelle (MSC) levering og sporing i en musemodel af traumatisk hjerneskade. Superparamagnetiske jernoxid nanopartikler er ansat som en MRI-sonde (magnetisk resonans imaging) til MSC-mærkning og ikke-invasiv in vivo-sporing efter intranasal levering ved hjælp af MRI i realtid.

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Medicin intranasal levering celle sporing SPIO celle mærkning in vivo Imaging traumatisk hjerneskade
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