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JoVE Journal Genetics
Assisted Selection of Biomarkers by Linear Discriminant Analysis Effect Size (LEfSe) in Microbiome Data
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Assisted Selection of Biomarkers by Linear Discriminant Analysis Effect Size (LEfSe) in Microbiome Data

Article DOI: 10.3791/61715-v • 04:57 min • May 16th, 2022
May 16th, 2022 •
*1, *2, 3
1Marine Resources Research Centre, Tianjin Research Institute for Water Transport Engineering, M.O.T., 2Key Laboratory of Regional Energy Systems Optimization, Ministry of Education, College of Environmental Science and Engineering, North China Electric Power University, 3School of Environmental Science and Engineering, Huazhong University of Science and Technology
* These authors contributed equally

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Summary
Automatic Translation

LEfSe (LDA Effect Size) is a tool for high-dimensional biomarker mining to identify genomic features (such as genes, pathways, and taxonomies) that significantly characterize two or more groups in microbiome data.

Tags

Linear Discriminant Analysis Effect Size Biomarkers Microbiome Data Statistical Differences Genomic Biomarkers Procedure Steps Conda Environment Data Formatting Command Execution Effect Size Calculation Data Analysis Biomarker Visualization
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