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JoVE Journal
Bioengineering

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Toksicitetsskærme i humane retinale organoider til farmaceutisk opdagelse
 
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Toksicitetsskærme i humane retinale organoider til farmaceutisk opdagelse

Article DOI: 10.3791/62269-v 07:45 min March 4th, 2021
March 4th, 2021

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Summary

Please note that all translations are automatically generated.

Click here for the English version.

Her præsenterer vi en trinvis protokol til generering af modne humane retinale organoider og udnytter dem i et fotoreceptortoksicitetsassay for at identificere farmaceutiske kandidater til den aldersrelaterede retinale degenerative sygdom makulær telangiectasia type 2 (MacTel).

Tags

Denne måned i JoVE udgave 169 retinal organoid organoid retinal degeneration MacTel sphingolipid fotoreceptor fenofibrat TUNEL farvning lægemiddel skærm lipid toksicitet
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