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JoVE Journal Chemistry
Radiosyntese av 1-(2-[18F]Fluoroethyl)-L-Tryptophan ved hjelp av en one-pot, to-trinns protokoll
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Radiosyntese av 1-(2-[18F]Fluoroethyl)-L-Tryptophan ved hjelp av en one-pot, to-trinns protokoll

Article DOI: 10.3791/63025-v • 08:33 min • September 21st, 2021
September 21st, 2021 •
1,2, 1,2, 1,2, 2, 3, 1,2, 1,4
1Diagnostic & Research PET/MRI Center, Nemours/Alfred I. duPont Hospital for Children, 2Department of Radiology, Nemours/Alfred I. duPont Hospital for Children, 3Department of Neurology, Nemours/Alfred I. duPont Hospital for Children, 4Department of Biomedical Research, Nemours/Alfred I. duPont Hospital for Children

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Her beskriver vi radiosyntesen til 1-(2-[18F]Fluoroethyl)-L-tryptofan, et positronutslippstomografiavbildningsmiddel for å studere tryptofan metabolisme, ved hjelp av en en-pott, to-trinns strategi i et radiokjemisk syntesesystem med gode radiokjemiske utbytter, høyt enantiomerisk overskudd og høy pålitelighet.

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Kjemi utgave 175 1-(2-[18F]Fluoroethyl)-L-tryptofan radiosyntese tryptofan metabolisme PET-avbildning kynureninbane
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