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JoVE Journal
Biology

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用于体外评估药物诱导肝毒性的人肝脏微生理系统
 
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用于体外评估药物诱导肝毒性的人肝脏微生理系统

Article DOI: 10.3791/63389-v 11:06 min January 31st, 2022
January 31st, 2022

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Summary

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药物性肝损伤(DILI)是药物失败的主要原因。已经开发了一种协议来使用肝脏微生理系统(MPS)准确预测化合物的DILI责任。肝脏模型使用原代肝细胞的共培养和翻译相关终点来评估细胞对治疗的反应。

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生物学,第179期,
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