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JoVE Journal Cancer Research
Digital romlig profilering for karakterisering av mikromiljøet i voksen type diffust infiltrerende gliom
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Digital romlig profilering for karakterisering av mikromiljøet i voksen type diffust infiltrerende gliom

Article DOI: 10.3791/63620-v • 09:17 min • September 13th, 2022
September 13th, 2022 •
1, 2, 2, 3, 2, 2,4
1Department of Neurology, Dartmouth-Hitchcock Medical Center, 2Department of Pathology and Laboratory Medicine, Dartmouth-Hitchcock Medical Center, 3Department of Neurosurgery, Dartmouth-Hitchcock Medical Center, 4Dartmouth Cancer Center, Dartmouth-Hitchcock Medical Center

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Proteomisk dysregulering spiller en viktig rolle i spredningen av diffust infiltrerende gliomer, men flere relevante proteiner forblir uidentifiserte. Digital romlig prosessering (DSP) tilbyr en effektiv, høy gjennomstrømningsmetode for å karakterisere differensialuttrykket av kandidatproteiner som kan bidra til invasjon og migrasjon av infiltrative gliomer.

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