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JoVE Journal
Immunology and Infection
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利用利什曼原虫破译毛孔形成毒素的分子机制和功能
 
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利用利什曼原虫破译毛孔形成毒素的分子机制和功能

Article DOI: 10.3791/64341-v 08:17 min October 28th, 2022
October 28th, 2022

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Summary

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Click here for the English version.

这里介绍的是使用 利什曼原虫主要 前鞭毛体来确定孔形成毒素诱导的结合、细胞毒性和信号传导的方案。提供了链球菌溶血素O的概念验证。其他毒素也可用于利用 杆菌 中可用的遗传突变体来确定毒素抗性的新机制。

Tags

免疫学与感染,第188期,肌醇磷酸神经酰胺,细胞毒性,膜修复,孔形成毒素,甾醇,鞘脂
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