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JoVE Journal Bioengineering
Cellulär affinitet av partikelstabiliserad emulsion för att öka antigeninternalisering
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Cellulär affinitet av partikelstabiliserad emulsion för att öka antigeninternalisering

Article DOI: 10.3791/64406-v • 10:06 min • September 2nd, 2022
September 2nd, 2022 •
*1,2,3, *3,4, 3,4, 3, 1,2
1Graduate School of Bio-Applications and Systems Engineering, Tokyo University of Agriculture and Technology, 2Institute of Global Innovation Research, Tokyo University of Agriculture and Technology, 3State Key Laboratory of Biochemical Engineering, Institute of Process Engineering, Chinese Academy of Sciences, 4University of Chinese Academy of Sciences
* These authors contributed equally

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För att rationellt utforma effektiva adjuvanser utvecklade vi poly-mjölksyra-co-glykolsyra nanopartikelstabiliserad Pickering-emulsion (PNPE). PNPE hade unik mjukhet och ett hydrofobt gränssnitt för potent cellulär kontakt och erbjöd antigenbelastning med högt innehåll, vilket förbättrade leveranssystemets cellulära affinitet till antigenpresenterande celler och inducerade effektiv internalisering av antigener.

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Bioengineering utgåva 187
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