Als Patients
Als Patients - Related Videos
08:10
Proper Adjustment of Patient Attire during the Physical Exam
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2023
Source: Jaideep S. Talwalkar, MD, and Joseph Donroe, MD, Internal Medicine and Pediatrics, Yale School of Medicine, New Haven, CT In order to optimize the predictive value of the physical examination, the provider must perform maneuvers correctly. The proper use of drapes is an important component of correctly performing physical examination maneuvers. Skin lesions are missed when "inspection" occurs through clothing, crackles are erroneously reported when the lungs are examined through a...
05:45
Quantitative Immunohistochemistry of the Cellular Microenvironment in Patient Glioblastoma Resections
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Cited by 10 •
2017
This protocol was developed to quantitatively identify tumor microenvironment components in glioblastoma patient resections using chromogenic immunohistochemistry and ImageJ.
08:40
Methyl-binding DNA capture Sequencing for Patient Tissues
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Cited by 1 •
2016
Here we present a protocol to investigate genome wide DNA methylation in large scale clinical patient screening studies using the Methyl-Binding DNA Capture sequencing (MBDCap-seq or MBD-seq) technology and the subsequent bioinformatics analysis pipeline.
11:10
Isolation of Human Islets from Partially Pancreatectomized Patients
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Cited by 10 •
2011
The supply of type 2 diabetic islets for research is insufficient. Here we share our protocol for isolating islets from patients undergoing partial pancreatectomy. This approach represents a unique venue for obtaining islets from type 2 diabetic and clinically matched non-diabetic subjects in adequate numbers for basic and clinical studies.
08:50
Assessment of Vascular Function in Patients With Chronic Kidney Disease
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Cited by 25 •
2014
The degree of vascular dysfunction and contributing physiological mechanisms can be assessed in patients with chronic kidney disease by measuring brachial artery flow-mediated dilation, aortic pulse-wave velocity, and vascular endothelial cell protein expression.
FAQs
Damage involving upper and lower motor neurons can occur alongside changes in emotional expression, executive function, social conduct, or decision-making. This means clinicians should consider behavioral findings together with movement-related symptoms rather than interpreting either domain in isolation. Linking neurological and behavioral observations can support a more complete understanding of an individual’s needs.
Behavioral effects are not uniform because ALS patients may show different combinations of emotional, executive, social, and decision-making changes. Some individuals may have noticeable behavioral symptoms, while others may have few or none. This variability makes individualized evaluation important and prevents clinicians from assuming that a particular behavioral pattern applies to every person with ALS.
Clinicians compare observed behavior with the broader clinical picture, including emotional expression, executive function, social conduct, decision-making, communication, and movement-related difficulties. The goal is not to label every behavioral change as neurological. Recognizing understandable psychological responses to disability alongside possible neurological effects leads to more balanced interpretation and more appropriate support.
Behavioral evaluation examines areas such as emotional expression, executive function, social conduct, and decision-making, while considering the person’s movement and communication difficulties. It helps identify whether observed changes may reflect neurological effects, responses to disability, or both. The resulting information can contribute to communication planning, caregiver support, safety planning, and personalized care.
Information about emotional expression, executive function, social conduct, and decision-making can help care teams adapt communication strategies to the individual. Considering these findings alongside movement and communication difficulties may clarify how a person expresses needs or participates in decisions. This individualized approach can make interactions more responsive and support comprehensive care.
Behavioral changes may affect social conduct, decision-making, emotional expression, or executive function, so caregivers and clinicians may need to plan support around the individual’s specific pattern. Behavioral evaluation provides information that can guide safety planning and caregiver responses. It also helps distinguish support needs from assumptions about motivation or understandable reactions to disability.
Studying behavior adds information beyond movement-related symptoms and can improve understanding of how ALS progresses across individuals. It also helps researchers examine the overlap between motor neuron disease and frontotemporal disorders. Behavioral observations therefore contribute both to individualized clinical assessment and to broader research on neurological changes associated with ALS.