Lesion Study
Lesion Study - Related Videos
05:51
A Human Ex Vivo Atherosclerotic Plaque Model to Study Lesion Biology
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Cited by 13 •
2014
Atherosclerosis is a chronic inflammatory process. This manuscript illustrates an easy to use ex vivo model to investigate fresh carotid or coronary artery plaques. The ex vivo model allows for the investigation of potential substances on the inflammatory milieu in human atherosclerotic lesions and results can be analyzed by various methods.
12:43
Advanced Confocal Microscopy Techniques to Study Protein-protein Interactions and Kinetics at DNA Lesions
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Cited by 8 •
2017
Laser microirradiation is a useful tool for studies of DNA repair in living cells. A methodological approach for the use of UVA lasers to induce various DNA lesions is shown. We have optimized a method for local microirradiation that maintains the normal cell cycle; thus, irradiated cells proceed through mitosis.
08:16
Comparative Lesions Analysis Through a Targeted Sequencing Approach
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2019
This article describes a method to identify clonal and subclonal alterations among different specimens from a given patient. Although the experiments described here focus on a specific tumor type, the approach is broadly applicable to other solid tumors.
08:40
Photothrombotic Ischemia: A Minimally Invasive and Reproducible Photochemical Cortical Lesion Model for Mouse Stroke Studies
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Cited by 226 •
2013
Photothrombosis is a quick, minimally-invasive technique for inducing small and well-delimited infarction in areas of interest in highly reproducible manner. It is particularly suitable for studying cellular and molecular responses underlying brain plasticity in transgenic mice.
09:22
Sectioning Mammary Gland Whole Mounts for Lesion Identification
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Cited by 13 •
2017
We developed a method to successfully remove, process, section, and stain, for histopathological evaluation, mammary tissue that had originally been fixed on slides as whole mounts. This method may promote the collection and evaluation of mammary gland whole mounts in reproductive and developmental test guideline studies.
FAQs
The critical comparison is between subjects with the lesion and healthy controls. If the groups differ on a measured behavior, the pattern provides evidence that the damaged region or pathway contributes to that behavior. This comparison strengthens causal inference beyond simply observing a relationship between neural activity and behavior alone.
Lesion location matters because damage can interrupt a particular brain region or neural pathway rather than the entire nervous system. Researchers therefore interpret behavioral changes in relation to the circuitry affected. This approach helps determine whether altered learning, memory, movement, or motivation is associated with the disrupted system under study.
Behavioral testing can target several outcome domains, including learning, memory, movement, and motivation. Matching the measurement to the suspected neural function helps investigators evaluate which behaviors change after disruption. The resulting pattern supplies evidence about the contribution of the affected circuitry and guides interpretation of its role in behavior.
Because lesion studies provide evidence for causal relationships, their findings can guide hypotheses tested with brain imaging, electrophysiology, or targeted neural manipulation. These methods therefore work together: lesion results identify a possible structure-behavior link, while complementary approaches can further examine the associated neural system and refine explanations of its function.
An investigation typically begins by creating or analyzing a lesion in a defined brain region or neural pathway. Researchers then assess behavior in the affected subjects and compare results with healthy controls. The measured tasks may address learning, memory, movement, motivation, or another behavioral outcome relevant to the neural system.
They are particularly informative when researchers need evidence about whether a neural structure or pathway contributes causally to behavior. In behavioral neuroscience and neuropsychology, the approach can connect disrupted circuitry with measurable changes and help interpret neurological disorders. It also provides a basis for developing hypotheses for follow-up experiments.
Researchers should relate the observed change to the damaged region or pathway and to the specific behavior measured. A difference in learning, memory, movement, or motivation supports an inference about the contribution of that circuitry, rather than automatically establishing that the structure controls every aspect of behavior.
They can reveal how disrupted neural systems relate to behavioral symptoms and clarify the functional significance of brain structures. This makes lesion evidence useful for interpreting neurological disorders and for selecting questions that can be examined with imaging, electrophysiology, or targeted neural manipulation in subsequent work.