Particle Distribution

Particle distribution describes how particles are arranged, dispersed, or concentrated within a system, making it essential for understanding chemical behavior and biological organization. In biochemistry, distributions arise from processes such as diffusion, random molecular motion, concentration gradients, and interactions among molecules, with equilibrium determining how particles occupy available space or states. Analyzing particle distribution helps explain solute transport, reaction kinetics, molecular binding, and the organization of biomolecules in cells and solutions. These principles support interpretation of biochemical experiments, formulation of medicines, and the design of systems that depend on controlled concentration, mixing, or separation.

Particle Distribution - Related Videos

Research

JoVE Journal - Engineering

Characterization of Nanocrystal Size Distribution using Raman Spectroscopy with a Multi-particle Phonon Confinement Model

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Cited by 10 •

2015

We demonstrate how to determine the size distribution of semiconductor nanocrystals in a quantitative manner using Raman spectroscopy employing an analytically defined multi-particle phonon confinement model. Results obtained are in excellent agreement with the other size analysis techniques like transmission electron microscopy and photoluminescence spectroscopy.

Research

JoVE Journal - Chemistry
Free Sample

Measurement of Particle Size Distribution in Turbid Solutions by Dynamic Light Scattering Microscopy

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Cited by 24 •

2017

A protocol for the direct measurement of particle size distribution in concentrated solutions using dynamic light scattering microscopy is presented.

Education

JoVE Core - Chemistry

Subatomic Particles

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2020

Dalton was only partially correct about the particles that make up matter. All matter is composed of atoms, and atoms are composed of three smaller subatomic particles: protons, neutrons, and electrons. These three particles account for the mass and the charge of an atom. The Discovery of the Electron The first clue about the subatomic structure came at the end of the 19th century when J.J. Thomson discovered the electron using a cathode ray tube. This apparatus consisted of a sealed glass...

Concentration and Purification of Viral Particles

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2026

Source: Fricano-Kugler, C. J., et al. Designing, Packaging, and Delivery of High Titer CRISPR Retro and Lentiviruses via Stereotaxic Injection. J. Vis. Exp. (2016).This video demonstrates the step-by-step process for concentrating and purifying lentiviral particles from a mixed suspension containing host cell debris. The procedure utilizes centrifugation, filtration, and PEG-salt precipitation to isolate viral particles while removing soluble impurities. The final product is resuspended in a...

Drug Distribution: Volume of Distribution

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2023

The volume of distribution refers to the theoretical volume necessary to contain the entire amount of an administered drug at the same concentration observed in the blood plasma. The body's intracellular fluid compartment, which makes up two-thirds of the total body water, is contrasted with the extracellular fluid compartment—comprising plasma and interstitial fluid—that accounts for one-third. The volume of distribution can vary depending on the characteristics of the drug.

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