Bubble Cloud Generation

Bubble cloud generation is the controlled formation of many gas bubbles within a liquid, an important process for manipulating fluids, particles, and biological systems in bioengineering. It typically occurs when dissolved gas comes out of solution or when an applied acoustic or mechanical force nucleates bubbles that grow, interact, and sometimes coalesce. The resulting bubble cloud can alter local fluid flow, pressure, and mass transfer, supporting applications such as mixing, emulsification, cell processing, imaging, and targeted delivery. Controlling bubble size, distribution, stability, and collapse is essential for achieving reproducible performance while limiting unwanted effects on cells and tissues.

Bubble Cloud Generation - Related Videos

Education

JoVE Core - Physics

Excess Pressure Inside a Drop and a Bubble

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2023

The shape of a small drop of liquid can be considered spherical, neglecting the effect of gravity. This drop can further be considered as two equal hemispherical drops put together due to surface tension. The forces acting on the spherical drop are due to the pressure of the liquid inside the drop, the pressure due to air outside the drop, and the force due to the surface tension acting on the two hemispherical drops. where γ corresponds to the surface tension. Recalling that the force per...

Research

JoVE Journal - Engineering

Synthesis of Phase-shift Nanoemulsions with Narrow Size Distributions for Acoustic Droplet Vaporization and Bubble-enhanced Ultrasound-mediated Ablation

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Cited by 18 •

2012

Phase-shift nanoemulsions (PSNE) can be vaporized using high intensity focused ultrasound to enhance localized heating and improve thermal ablation in tumors. In this report, the preparation of stable PSNE with a narrow size distribution is described. Furthermore, the impact of vaporized PSNE on ultrasound-mediated ablation is demonstrated in tissue-mimicking phantoms.

Research

JoVE Journal - Engineering
Free Sample

Knowledge Based Cloud FE Simulation of Sheet Metal Forming Processes

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Cited by 10 •

2016

The following paper presents a novel FE simulation technique (KBC-FE), which reduces computational cost by performing simulations on a cloud computing environment, through the application of individual modules. Moreover, it establishes a seamless collaborative network between world leading scientists, enabling the integration of cutting edge knowledge modules into FE simulations.

Induction of Microstreaming by Nonspherical Bubble Oscillations in an Acoustic Levitation System

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Cited by 2 •

2021

A fast and reliable technique is proposed to control the shape oscillations of a single, trapped acoustic bubble that is based on coalescence technique between two bubbles. The steady-state, symmetry-controlled bubble shape oscillations allow analysis of the fluid flow generated in the vicinity of the bubble interface.

A Microfluidic System with Surface Patterning for Investigating Cavitation Bubble(s)–Cell Interaction and the Resultant Bioeffects at the Single-cell Level

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Cited by 8 •

2017

A microfluidic chip was fabricated to produce pairs of gold dots for tandem bubble generation and fibronectin-coated islands for single-cell patterning nearby. The resultant flow field was characterized by particle image velocimetry and was employed to study various bioeffects, including cell membrane poration, membrane deformation, and intracellular calcium response.

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