Extra-articular Fixation
Extra-articular Fixation - Related Videos
08:53
Whole Animal Perfusion Fixation for Rodents
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Cited by 531 •
2012
Here we describe a low-cost, rapid, controlled and uniform fixation procedure using 4% paraformaldehyde perfused via the vascular system: through the heart of the rat to obtain the best possible preservation of the brain.
01:03
Fixation and Sectioning
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2023
Two basic types of preparation are used to visualize specimens with a light microscope: wet mounts and fixed specimens. The simplest type of preparation is the wet mount, in which the specimen is placed in a drop of liquid on the slide. A liquid specimen can be directly deposited on the slide using a dropper. Solid specimens, such as skin scraping, can be placed on the slide before adding a drop of liquid to prepare the wet mount. Sometimes the liquid is simply water, but stains are often added...
10:21
Protocol for HER2 FISH Using a Non-cross-linking, Formalin-free Tissue Fixative to Combine Advantages of Cryo-preservation and Formalin Fixation
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Cited by 3 •
2017
Fluorescence in-situ hybridization (FISH) is often required in combination with histopathology and molecular diagnostics for selection of therapy in personalized medicine. A novel non-cross-linking, formalin-free tissue fixative that allows high quality morphologic, molecular and FISH analyses from the same specimen by addition of a post-fixation step before FISH is presented.
06:57
Instillation and Fixation Methods Useful in Mouse Lung Cancer Research
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Cited by 48 •
2015
The goal of this paper is to describe simple methods that will greatly aid in the setup and analysis of mouse lungs with lung cancer or other pathologies. We present 3 protocols to simply and reliably carry out lung instillations, fixation, and lung volume measurements.
01:28
Carbon-dioxide Fixation
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2025
Carbon dioxide fixation in prokaryotes enables the assimilation of inorganic carbon into organic molecules, supporting biosynthetic pathways, sustaining ecosystems, and contributing to the global carbon cycle. It also has industrial applications in carbon capture and bioproduct synthesis. Autotrophic organisms rely on this process to utilize CO₂ as a carbon source in diverse environments.The Calvin CycleThe Calvin cycle is the most widespread carbon fixation mechanism, primarily used by...
FAQs
Extra-articular fixation transfers loads across the affected bone while maintaining alignment and joint congruity. Its mechanical purpose is to provide enough stability for a fracture or osteotomy without requiring hardware placement within the joint surface. In bioengineering studies, researchers therefore examine whether an implant configuration balances load transfer, structural support, and preservation of nearby articular cartilage.
Keeping fixation hardware outside the joint surface helps limit disruption of articular cartilage while supporting stabilization of the altered bone. This design priority connects mechanical performance with preservation of joint function. Evaluations can consequently consider not only whether the construct maintains alignment, but also whether it protects the joint environment during the intended repair or reconstruction.
Physiological loading provides a basis for examining how an implant construct responds to forces relevant to the body. Under these loading conditions, bioengineers can assess fixation performance, load transfer, and maintenance of alignment. The resulting information helps determine whether the design offers appropriate stability while supporting bone healing and limiting mechanical compromise of joint function.
Plates, screws, wires, and external fixation components serve as structural elements that transfer mechanical loads across a fractured or surgically altered region. Their inclusion in a construct allows researchers to study how fixation supports stability and alignment without placing components within the adjacent joint surface. The relevant outcome is the overall balance between mechanical support and tissue preservation.
A comprehensive evaluation can examine fixation performance, bone healing, implant mechanics, alignment, and protection of joint function. These outcomes address different aspects of success: mechanical behavior describes how the construct carries load, while healing and alignment indicate its effect on the treated bone. Joint-related assessment further considers whether stabilization preserves the surrounding articular environment.
This strategy is particularly relevant to fracture repair and osteotomy research. In both settings, investigators must consider how stabilization affects the altered bone while maintaining appropriate alignment and protecting nearby joint structures. It also provides a framework for comparing implant designs according to their mechanical behavior, contribution to healing, and ability to support continued joint function.
In bioengineering, the approach links implant design to measurable biological and mechanical outcomes. Researchers can evaluate whether a construct transfers physiological loads effectively, maintains stability and alignment, and supports bone healing without compromising joint function. This connection makes the strategy useful for studying implant mechanics alongside tissue preservation, rather than treating structural stability as the only endpoint.