Near Infrared Laser Triggered Release
Near Infrared Laser Triggered Release - Related Videos
09:38
Characterizing Far-infrared Laser Emissions and the Measurement of Their Frequencies
0 Views •
Cited by 4 •
2015
We describe the generation of far-infrared radiation using an optically pumped molecular laser along with the measurement of their frequencies with heterodyne techniques. The experimental system and techniques are demonstrated using difluoromethane (CH2F2) as the laser medium whose results include three new laser emissions and eight measured laser frequencies.
07:47
Custom-designed Laser-based Heating Apparatus for Triggered Release of Cisplatin from Thermosensitive Liposomes with Magnetic Resonance Image Guidance
0 Views •
Cited by 17 •
2015
AN MRI-compatible custom-designed laser-based heating apparatus has been developed to provide local heating of subcutaneous tumors in order to activate release of agents from thermosensitive liposomes specifically at the tumor region.
08:39
Magnetic and Thermal-sensitive Poly(N-isopropylacrylamide)-based Microgels for Magnetically Triggered Controlled Release
0 Views •
Cited by 9 •
2017
This manuscript describes the preparation of magnetic and thermal-sensitive microgels via a temperature-induced emulsion without chemical reaction. These sensitive microgels were synthesized by mixing poly(N-isopropylacrylamide) (PNIPAAm), polyethylenimine (PEI) and Fe3O4-NH2 nanoparticles for the potential use in magnetically and thermally triggered drug-release.
09:31
Measurement of Tension Release During Laser Induced Axon Lesion to Evaluate Axonal Adhesion to the Substrate at Piconewton and Millisecond Resolution
0 Views •
Cited by 1 •
2013
We measured the tension release in an axon that was partially lesioned with a laser dissector by simultaneous force spectroscopy measurement performed on an optically-trapped probe adhered to the membrane of the axon. The developed experimental protocol evaluates the axon adhesion to the culture substrate.
11:20
An Integrated System to Remotely Trigger Intracellular Signal Transduction by Upconversion Nanoparticle-mediated Kinase Photoactivation
0 Views •
Cited by 1 •
2017
In this protocol, caged protein kinase A (PKA), a cellular signal transduction bioeffector, was immobilized on a nanoparticle surface, microinjected into the cytosol, and activated by the upconverted UV light from near-infrared (NIR) irradiation, inducing downstream stress fiber disintegration in the cytosol.
FAQs
The response can occur through more than one pathway. Absorbed near infrared energy may produce localized heating, while other responsive designs undergo structural changes. Those changes can disrupt the carrier, open pores, or cleave light-sensitive linkers. The selected pathway determines how the cargo leaves its carrier and allows the release event to remain externally controlled.
Engineered carriers provide the material framework that holds the cargo and responds to illumination. Their responsive components may convert absorbed energy into heat, rearrange the structure, create pores, or break light-sensitive linkers. Consequently, carrier design connects the laser stimulus to the release mechanism and determines how drugs, proteins, or other biomolecules leave the carrier.
External timing matters because release does not have to occur continuously or indiscriminately. Illumination can be applied at a selected location and time, enabling researchers to coordinate cargo delivery with a desired site or experimental event. This spatial and temporal control may reduce exposure away from the target and improve control over treatment or biomolecule delivery.
A typical workflow begins with placing the cargo inside or associating it with an engineered responsive carrier. The carrier is then positioned in the intended experimental or therapeutic setting, followed by near infrared laser illumination at the selected time and location. Absorption triggers heating or structural disruption, and pore formation, carrier breakdown, or linker cleavage releases the cargo.
The approach is relevant when delivery must be controlled rather than simply distributed. In bioengineering, described applications include targeted therapy, biosensing, tissue engineering, and smart implantable or injectable delivery systems. It can be adapted to release drugs, proteins, and other biomolecules, making the same control principle useful across therapeutic, analytical, and tissue-engineering settings.
Implantable and injectable systems benefit from an externally controlled trigger because the carrier can be integrated into a delivery platform while release remains governed by illumination. This design supports access to drugs, proteins, or other biomolecules at selected sites and times. In bioengineering, that combination is relevant to smart systems intended to improve treatment control and limit off-target exposure.