Tandem Bubbles
Tandem Bubbles - Related Videos
07:09
Tandem Mass Spectrometry
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2023
In tandem mass spectrometry a biomolecule of interest is isolated from a biological sample, and then fragmented into multiple subunits in order to help elucidate its composition and sequence. This is accomplished by having mass spectrometers in series. The first spectrometer ionizes a sample and filter ions of a specific mass to charge ratio. Filtered ions are then fragmented and passed to a second mass spectrometer where the fragments are analyzed. This video introduces the principles of...
01:13
Excess Pressure Inside a Drop and a Bubble
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2023
The shape of a small drop of liquid can be considered spherical, neglecting the effect of gravity. This drop can further be considered as two equal hemispherical drops put together due to surface tension. The forces acting on the spherical drop are due to the pressure of the liquid inside the drop, the pressure due to air outside the drop, and the force due to the surface tension acting on the two hemispherical drops. where γ corresponds to the surface tension. Recalling that the force per...
11:14
A Microfluidic System with Surface Patterning for Investigating Cavitation Bubble(s)–Cell Interaction and the Resultant Bioeffects at the Single-cell Level
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Cited by 8 •
2017
A microfluidic chip was fabricated to produce pairs of gold dots for tandem bubble generation and fibronectin-coated islands for single-cell patterning nearby. The resultant flow field was characterized by particle image velocimetry and was employed to study various bioeffects, including cell membrane poration, membrane deformation, and intracellular calcium response.
03:01
Detection of Fish Pathogens Using Variable Number Tandem Repeat (VNTR) Analysis
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2025
Source: Gulla, S., et al. Multi-locus Variable-number Tandem-repeat Analysis of the Fish-pathogenic Bacterium Yersinia ruckeri by Multiplex PCR and Capillary Electrophoresis. J. Vis. Exp. (2019).This video demonstrates the procedure for separating fluorescently labeled variable number tandem repeat (VNTR) amplicons, derived from a fish-pathogenic bacterium, using capillary electrophoresis to generate size-specific electropherogram profiles for bacterial identification.
08:19
Induction of Microstreaming by Nonspherical Bubble Oscillations in an Acoustic Levitation System
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Cited by 2 •
2021
A fast and reliable technique is proposed to control the shape oscillations of a single, trapped acoustic bubble that is based on coalescence technique between two bubbles. The steady-state, symmetry-controlled bubble shape oscillations allow analysis of the fluid flow generated in the vicinity of the bubble interface.
FAQs
Interaction begins when the expansion or collapse of one bubble sends a pressure wave and liquid motion through the surrounding fluid. The neighboring bubble then responds, altering its own deformation and motion, which feeds back into the pair’s subsequent behavior. This coupling explains why tandem bubbles can produce outcomes that an isolated bubble would not, a key consideration in microscale fluid design.
Asymmetric deformation can arise because each bubble experiences the other’s pressure waves and induced liquid motion rather than a uniform, isolated-bubble environment. The same coupling may lead the bubbles toward attraction or repulsion and can generate localized microjets. These responses are important because they concentrate mechanical effects in selected regions of a fluid.
Localized microjets result from the concentrated liquid motion associated with coupled bubble dynamics. Because the neighboring bubble modifies the pressure and flow environment, deformation need not remain symmetric, and collapse can be associated with fluid motion focused into a small region. In bioengineering experiments, these jets are relevant for examining or exploiting highly localized mechanical effects.
Tandem bubbles can be relevant to microfluidic transport because their coupled expansion, collapse, and liquid motion provide a way to influence fluid behavior at small scales. Rather than treating each bubble as an independent element, researchers can consider the pair’s combined pressure-wave and flow effects. This perspective may support designs seeking more controlled movement within biomedical microfluidic devices.
In cell manipulation, the pair’s value lies in its ability to produce microscale forces through bubble interaction. Asymmetric deformation, attraction or repulsion, and localized microjets offer distinct mechanical responses that can be studied in biological settings. The same principle supports targeted mechanical stimulation, where researchers examine how confined fluid forces might be applied to a selected biological region.
Researchers can evaluate a tandem-bubble system by examining how each bubble expands and collapses, how the neighbor deforms, whether the pair attracts or repels, and whether localized microjets appear. These observations connect bubble-scale behavior with broader bioengineering goals, including microfluidic transport, cell manipulation, targeted stimulation, and cavitation-based processing, while helping guide more precise device and experimental-model design.