4d Flow Mri

4D flow MRI is a time-resolved, three-dimensional phase-contrast magnetic resonance technique that measures fluid velocity and flow direction, providing a noninvasive view of cardiovascular hemodynamics. During image acquisition, motion-encoding magnetic field gradients translate velocity-induced phase shifts in the MR signal into vector blood-flow data, while cardiac gating captures changes across the heartbeat. The resulting datasets can quantify flow rates, visualize streamlines, and reveal complex patterns such as turbulence, recirculation, and abnormal wall shear. In biology and cardiovascular research, 4D flow MRI supports studies of vessel function, congenital heart disease, aneurysms, and treatment planning without ionizing radiation.

4d Flow Mri - Related Videos

Research

JoVE Journal - Biology

4D Microscopy of Yeast

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Cited by 12 •

2019

This protocol describes the analysis of fluorescently labeled intracellular compartments in budding yeast using multi-color 4D (time-lapse 3D) confocal microscopy. The imaging parameters are chosen to capture adequate signals while limiting photodamage. Custom ImageJ plugins allow labeled structures to be tracked and quantitatively analyzed.

Research

JoVE Journal - Neuroscience
Free Sample

Optogenetic Functional MRI

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Cited by 15 •

2016

This protocol describes the steps and data analysis required to successfully perform optogenetic functional magnetic resonance imaging (ofMRI). ofMRI is a novel technique that combines high-field fMRI readout with optogenetic stimulation, allowing for cell type-specific mapping of functional neural circuits and their dynamics across the whole living brain.

MRI-guided dmPFC-rTMS as a Treatment for Treatment-resistant Major Depressive Disorder

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Cited by 31 •

2015

Here we outline the procedure for MRI-guided repetitive transcranial magnetic stimulation to the dorsomedial prefrontal cortex as an experimental treatment for major depressive disorder.

Education

JoVE Science Education - Engineering

Computational Fluid Dynamics Simulations of Blood Flow in a Cerebral Aneurysm

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2023

Source: Joseph C. Muskat, Vitaliy L. Rayz, and Craig J. Goergen, Weldon School of Biomedical Engineering, Purdue University, West Lafayette, Indiana The objective of this video is to describe recent advancements of computational fluid dynamic (CFD) simulations based on patient- or animal-specific vasculature. Here, subject-based vessel segmentations were created, and, using a combination of open-source and commercial tools, a high-resolution numerical solution was determined within a flow model.

Hyperpolarized Xenon for NMR and MRI Applications

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Cited by 28 •

2012

The production of hyperpolarized xenon by means of spin exchange optical pumping (SEOP) is described. This method yields a ~10000-fold enhancement of the nuclear spin polarization of Xe-129 and has applications in nuclear magnetic resonance spectroscopy and imaging. Examples of gas phase and solution state experiments are given.

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