Bacterial Migration

Bacterial migration is the directed movement of bacterial cells through liquid or across surfaces, enabling them to locate favorable conditions and respond to environmental change. Many bacteria move using rotating flagella, whose activity is regulated by chemotaxis signaling pathways that compare attractant or repellent concentrations and adjust swimming direction; others use pili or surface-associated motility mechanisms. Migration supports colonization, biofilm formation, host infection, and access to nutrients, while collective movement can shape microbial communities. Studying bacterial migration helps researchers understand microbial ecology, infection biology, antibiotic responses, and the physical principles governing cell movement.

Bacterial Migration - Related Videos

Education

JoVE Science Education - Advanced Biology

The Transwell Migration Assay

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2023

Cells migration in response to chemical cues is crucial to development, immunity and disease states such as cancer. To quantify cell migration, a simple assay was developed in 1961 by Dr. Stephen Boyden, which is now known as the transwell migration assay or Boyden chamber assay. This set-up consists an insert which separates the wells of a multiwell plate into top and bottom compartments. Cells whose migration is to be studied are seeded into the top compartment and the chemoattractant...

An Introduction to Cell Motility and Migration

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2023

Cell motility and migration play important roles in both normal biology and in disease. On one hand, migration allows cells to generate complex tissues and organs during development, but on the other hand, the same mechanisms are used by tumor cells to move and spread in a process known as cancer metastasis. One of the primary cellular machineries that make cell movement possible is an intracellular network of myosin and actin molecules, together known as “actomyosin”, which creates a...

Research

JoVE EoE - Rodent Models

Bacterial Endophthalmitis Mouse Model: A Method for Generating Bacterial Endophthalmitis via Intravitreal Injection of Bacterial Suspension into Eye of Mouse

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2025

This video describes a method for generating a mouse model that mimics bacterial endophthalmitis – an intraocular infection resulting from a bacterial invasion into the eye’s vitreous cavity – via intravitreal injection of a bacterial suspension into the eye. This mouse model helps study the disease mechanism and evaluate therapeutics for it.

Migration

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2025

Migration is long-range, seasonal movement from one region or habitat to another. This common strategy, carried out by many different organisms around the world, is an adaptive response that typically corresponds to changes in an organism’s environment, like resource availability or climate. Migrations can involve huge groups of thousands of animals as well as single individuals traveling alone and can range from thousands of kilometers to just a few hundred meters. Why Animals Migrate For...

Quantitative Assessment of Human Neutrophil Migration Across a Cultured Bladder Epithelium

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Cited by 8 •

2013

We developed an in vitro model that mimics an important component of the acute inflammatory response during infection of the bladder with uropathogenic Escherichia coli. The transuroepithelial neutrophil migration assay enables quantitative assessment of human neutrophil migration across bladder epithelia, cultured on permeable supports, in response to bacterial infection or chemoattractant substances.

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