Chondroitin
Chondroitin - Related Videos
12:22
Synthesis of Thermogelling Poly(N-isopropylacrylamide)-graft-chondroitin Sulfate Composites with Alginate Microparticles for Tissue Engineering
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Cited by 11 •
2016
An injectable tissue engineering scaffold composed of poly(N-isopropylacrylamide)-graft-chondroitin sulfate (PNIPAAm-g-CS)-containing alginate microparticles was prepared. The adhesive strength, swelling properties and in vitro biocompatibility are analyzed in this study. The characterization techniques developed here may be applicable to other thermogelling systems.
05:55
Synthesis and Characterization of Placental Chondroitin Sulfate A (plCSA)-Targeting Lipid-Polymer Nanoparticles
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Cited by 12 •
2018
Here, we present a protocol for the synthesis of placental chondroitin sulfate A binding peptide (plCSA-BP)-conjugated lipid-polymer nanoparticles via single-step sonication and bioconjugate techniques. These particles constitute a novel tool for the targeted delivery of therapeutics to most human tumors and placental trophoblasts to treat cancers and placental disorders.
14:03
Transduction of Human Cells with Polymer-complexed Ecotropic Lentivirus for Enhanced Biosafety
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Cited by 8 •
2011
Lentiviruses are a valuable research tool for exploring gene function; however, researchers may wish to avoid production of pantropic lentivirus encoding known or suspected oncogenes. As an alternative, we present a safer protocol for use of ecotropic lentivirus on human cells modified to express the ecotropic receptor mSlc7a1.
20:14
Combining Peripheral Nerve Grafting and Matrix Modulation to Repair the Injured Rat Spinal Cord
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Cited by 21 •
2009
Traumatic injury to the spinal cord disrupts communication with the brain. To restore lost connectivity we utilize a peripheral nerve graft to provide a substratum for regenerating fibers in combination with neurotrophic factors and matrix-modulating enzymes to remove inhibitory molecules to promote long distance growth.
12:37
3D Hydrogel Scaffolds for Articular Chondrocyte Culture and Cartilage Generation
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Cited by 38 •
2015
Cartilage repair represents an unmet medical challenge and cell-based approaches to engineer human articular cartilage are a promising solution. Here, we describe three-dimensional (3D) biomimetic hydrogels as an ideal tool for the expansion and maturation of human articular chondrocytes.
FAQs
Its negatively charged sulfate groups help chondroitin-rich matrix regions attract water and ions. This hydration supports resistance to compression, which is especially important in tissues that must retain structure under physical load. The same charge-based behavior also helps organize interactions among extracellular matrix components and molecules.
When chondroitin links to a core protein, it contributes to a proteoglycan rather than acting only as an isolated carbohydrate chain. This organization places its sulfate-dependent hydration and molecular interactions within the extracellular matrix. As a result, chondroitin can participate in the structural arrangement of connective-tissue material and its physical properties.
In cartilage, chondroitin contributes to a hydrated extracellular environment that helps the tissue resist compression while retaining elasticity. Its water- and ion-attracting groups support the matrix conditions needed for these properties. Examining this relationship helps connect molecular composition with cartilage behavior, including how matrix organization contributes to joint biology.
Although cartilage contains especially high amounts, chondroitin contributes to connective-tissue structure and function more broadly. Its matrix interactions can therefore be considered in studies of tissue development as well as joint biology. This wider context matters because changes in extracellular organization may be relevant when investigating degenerative disease and tissue maintenance.
Chondroitin research can examine how connective tissues develop, how cartilage maintains hydration and elasticity, and how extracellular matrix organization relates to joint biology. It also provides context for investigating degenerative disease. These questions connect molecular properties with tissue-level outcomes, allowing researchers to relate carbohydrate structure to biological organization and function.
Its ability to support hydration, elasticity, and extracellular matrix interactions makes chondroitin relevant to biomaterial research and strategies for cartilage repair. Researchers can also consider these properties in the context of nutritional supplements. These applications arise from the same structural features that make chondroitin important in natural connective tissues.