Depth Filters

Depth filters are porous filtration devices that remove suspended particles throughout the thickness of a fibrous or granular medium, rather than trapping them only at a surface. In biology and bioprocessing, pressure-driven flow carries a liquid through interconnected pores, while particles are captured by size exclusion, entrapment, and adsorption; graded pore structures can retain progressively smaller contaminants. Depth filters are used to clarify cell culture harvests, lysates, and other biological fluids by reducing cells, cell debris, and aggregates before downstream purification. This prefiltration step helps protect membrane filters and chromatography systems, improves process reliability, and supports efficient production of research and therapeutic biomolecules.

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Education

JoVE Core - Electrical Engineering

Passive Filters

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2024

Passive filters are utilized to shape the frequency spectrum of signals across a diverse array of applications. These filters, using only passive elements like resistors (R), inductors (L), and capacitors (C), are capable of selectively allowing or blocking certain frequency ranges without the need for external power sources. Low-Pass Filters Low-pass filters are designed to transmit signals with frequencies lower than the cutoff frequency, ωc, and attenuate those above it. The cutoff frequency...

Research

JoVE Journal - Biology
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Evaluating the Effect of Coated Filters and Pre-Filters on the Infectivity and Concentration of Aerosolized Phi6 Virus

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2026

Here, we present a study to evaluate the anti-viral efficacy of copper- and silver-based surface coatings on air filters. Using a bioaerosol chamber and Phi6 bacteriophage, this method quantifies viral inactivation and mechanical filtration efficiency for self-sanitizing indoor air technologies.

Active Filters

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2025

Active filters are electronic circuits that use operational amplifiers (op-amps), resistors, and capacitors to filter out unwanted frequency components from a signal. A first-order low-pass active filter is designed to pass signals with a frequency lower than a certain cutoff frequency and attenuate frequencies higher than that cutoff frequency. The transfer function for a first-order low-pass active filter is: Where Af is the gain at low frequencies also known as the dc gain, s is the...

Uniform Depth Channel Flow

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2025

Uniform depth channel flow keeps fluid depth consistent along channels such as irrigation canals. In natural channels, such as rivers, approximate uniform flow is often assumed. This condition occurs when the channel’s bottom slope matches the energy slope, balancing potential energy lost from gravity with head loss due to shear stress. This balance prevents depth changes along the channel length, resulting in a steady, uniform flow.Uniform flow in open channels with a constant cross-section...

Depth Perception and Spatial Vision

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2024

Depth perception is the ability to perceive objects three-dimensionally. It relies on two types of cues: binocular and monocular. Binocular cues depend on the combination of images from both eyes and how the eyes work together. Since the eyes are in slightly different positions, each eye captures a slightly different image. This disparity between images, known as binocular disparity, helps the brain interpret depth. When the brain compares these images, it determines the distance to an object.

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