Double Circulation

Double circulation is a circulatory system in which blood passes through the heart twice during one complete circuit, enabling efficient transport of oxygen, nutrients, and wastes. In this arrangement, the pulmonary circuit carries deoxygenated blood from the heart to the lungs for gas exchange, while the systemic circuit delivers oxygenated blood from the heart to body tissues; a four-chambered heart keeps the two pathways separate and maintains appropriate pressure. Found in mammals, birds, and other vertebrates, double circulation supports high metabolic activity by improving oxygen delivery and carbon dioxide removal. Its organization also provides a foundation for studying heart function, respiratory physiology, and cardiovascular disease.

Double Circulation - Related Videos

Education

JoVE Core - Anatomy and Physiology

Fetal Circulation

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2024

Fetal circulation is a unique system that facilitates the exchange of gases, nutrients, and waste products between the developing fetus and the mother. This intricate process takes place through a special organ called the placenta. Two umbilical arteries transport blood from the fetus to the placenta. At the placenta, the blood absorbs oxygen and nutrients while simultaneously eliminating waste products. This oxygen-enriched and nutrient-rich blood then returns to the fetus through one...

Coronary Circulation

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2024

The heart, an organ critical to survival, gets nourishment not from the blood it pumps but from a separate circulation system known as coronary circulation. This is the shortest circulation in the body and is responsible for supplying the heart with the nutrients it needs to function effectively. Coronary circulation begins at the base of the aorta, where two main arteries arise—the left and right coronary arteries. These arteries encircle the heart in the coronary sulcus and supply the...

Education

JoVE Core - Molecular Biology
Free Sample

Fixing Double-strand Breaks

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2020

The double-stranded structure of DNA has two major advantages. First, it serves as a safe repository of genetic information where one strand serves as the back-up in case the other strand is damaged. Second, the double-helical structure can be wrapped around proteins called histones to form nucleosomes, which can then be tightly wound to form chromosomes. This way, DNA chains up to 2 inches long can be contained within microscopic structures in a cell. A double-stranded break not only damages...

Overview of Pulmonary Circulation

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2024

The pulmonary circulation is a vital system in our body that acts as a bridge between the respiratory and cardiovascular systems. It serves as a transport network for deoxygenated blood from the heart to the lungs and then returns oxygen-rich blood back to the heart. The process begins with the right ventricle of the heart pumping deoxygenated blood into the pulmonary trunk. This large vessel extends about 5 centimeters before splitting into the left and right pulmonary arteries. These arteries...

Research

JoVE Journal - Medicine

Isolation and Propagation of Circulating Tumor Cells from a Mouse Cancer Model

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Cited by 8 •

2015

Circulating tumor cells (CTCs) have been shown to play an important role in tumor metastasis. Here, a method for the isolation and propagation of CTCs from the whole blood of a syngeneic mouse tumor model of hepatocellular carcinoma (HCC) metastasis is described.

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