Eye Diseases

Eye diseases are disorders that impair the structure or function of the eye and can affect vision, comfort, or visual development. They arise when processes such as infection, inflammation, abnormal blood-vessel growth, genetic mutation, tissue degeneration, or disrupted fluid regulation damage the cornea, lens, retina, optic nerve, or surrounding tissues. Biological study of these conditions examines how cellular injury, immune responses, inherited changes, and altered signaling contribute to disease progression. This knowledge supports earlier diagnosis, risk assessment, and the development of treatments for conditions including cataracts, glaucoma, retinal degeneration, and diabetic eye disease, while informing strategies to preserve vision and prevent avoidable impairment.

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Research

JoVE Journal - Neuroscience

Characterizing the Relationship Between Eye Movement Parameters and Cognitive Functions in Non-demented Parkinson's Disease Patients with Eye Tracking

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Cited by 5 •

2019

Here, we present a protocol to study the relationship between the eye movement parameters and cognitive functions in non-demented Parkinson's disease patients. The experiment used an eye tracker to measure the saccadic amplitude and fixation duration in a visual search task. The correlation with performance in multi-domain cognitive tasks was subsequently measured.

Performing Injection into Palpebral Portion of the Superior Lacrimal Gland: A Technique for Inducing Dry Eye Disease in Rabbit Model

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2025

In this video, we show a procedure to induce aqueous-deficient dry eye disease in a rabbit model by injecting the palpebral portion of the superior lacrimal gland with Concanavalin A. This model is useful for pharmacokinetic and biodistribution assays of drugs for treating dry eye disease.

Comparing Objective Conjunctival Hyperemia Grading and the Ocular Surface Disease Index Score in Dry Eye Syndrome During COVID-19

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2022

The present protocol describes the cross-sectional research performed on 40 healthy subjects between the ages of 20 and 45 to assess the prevalence of dry eye syndrome (DES) during COVID-19. The OSDI survey evaluated DES, and the advanced ophthalmic systems (AOS) software was used to assess limbal redness.

Platelet-Rich Plasma Lysate for Treatment of Eye Surface Diseases

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Cited by 6 •

2022

Platelet lysates represent an emerging tool for the treatment of ocular surface diseases. Here, we propose a method for the preparation, dispensation, storage, and characterization of platelet lysate collected from platelet donors.

In Vivo Confocal Microscopy in the Diagnosis and Management of Dry Eye: A Focus on Imaging Protocols and Interpretation

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2025

This article demonstrates the operation and effect of in vivo confocal microscopy in the diagnosis and treatment of dry eye and investigates the application and outcomes of in vivo confocal microscopy to provide a basis for future research.

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