Keratin 14 Expression
Keratin 14 Expression - Related Videos
14:43
Synthesis of Keratin-based Nanofiber for Biomedical Engineering
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Cited by 12 •
2016
Electrospun nanofibers have a high surface area to weight ratio, excellent mechanical integrity, and support cell growth and proliferation. These nanofibers have a wide range of biomedical applications. Here we fabricate keratin/ PCL nanofibers, using the electrospinning technique, and characterize the fibers for possible applications in tissue engineering.
08:29
Preparation of Keratin Hydrolysate from Chicken Feathers and Its Application in Cosmetics
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Cited by 23 •
2017
The goal of the protocol is to prepare keratin hydrolysate from chicken feathers by alkaline-enzymatic hydrolysis and to test whether adding keratin hydrolysate into a cosmetics ointment base improves skin barrier function (heightening hydration and diminishing transepidermal water loss). Tests are conducted on men and woman volunteers.
07:59
Airfoil Behavior: Pressure Distribution over a Clark Y-14 Wing
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2023
Source: David Guo, College of Engineering, Technology, and Aeronautics (CETA), Southern New Hampshire University (SNHU), Manchester, New Hampshire An airfoil is a 2-dimensional wing section that represents critical wing performance characteristics. The pressure distribution and lift coefficient are important parameters that characterize the behavior of airfoils. The pressure distribution is directly related to the lift generated by airfoils. A Clark Y-14 airfoil, which is used in this...
11:16
Isolation of Protoplasts from Tissues of 14-day-old Seedlings of Arabidopsis thaliana
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Cited by 59 •
2009
This video shows a procedure for isolating intact protoplasts from tissues of 14-day-old seedlings of Arabidopsis. Given that the isolated protoplasts remain intact for at least 96h and are isolated from seedlings instead of one-month-old mature plants, this procedure expedites assays requiring intact protoplasts.
09:18
Clark Y-14 Wing Performance: Deployment of High-lift Devices (Flaps and Slats)
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2023
Source: David Guo, College of Engineering, Technology, and Aeronautics (CETA), Southern New Hampshire University (SNHU), Manchester, New Hampshire A wing is the major lift-generating apparatus in an airplane. Wing performance can be further enhanced by deploying high-lift devices, such as flaps (at the trailing edge) and slats (at the leading edge) during takeoff or landing. In this experiment, a wind tunnel is utilized to generate certain airspeeds, and a Clark Y-14 wing with a flap and slat...
FAQs
KRT14 works with keratin 5 to form heteropolymer networks, meaning filament structures built from two keratin types. These networks reinforce cellular architecture and help basal keratinocytes withstand mechanical stress. Studying this partnership is important because it connects molecular organization with the resilience and structural integrity of stratified squamous epithelia such as the epidermis.
Keratin 14 expression is regulated as keratinocytes move through biological states associated with proliferation, differentiation, and tissue injury. Consequently, its measurement can provide information about how epithelial cells are organized and responding within a tissue. This makes the marker useful for examining changes in epidermal biology rather than treating expression as an isolated molecular event.
Changes affecting KRT14 can compromise the filament network that supports cell architecture and mechanical strength. When this structural support is weakened, epithelial cells may become less resilient. This relationship provides a mechanistic basis for investigating how molecular defects in keratin systems contribute to skin disorders, including epidermolysis bullosa simplex, in which KRT14 mutations are relevant.
Measuring Keratin 14 expression helps researchers identify basal epithelial cells and evaluate the organization of the epidermis. Because expression is connected with keratinocyte behavior and tissue injury responses, the measurement can also help place cellular changes within a broader process of epithelial maintenance or regeneration. Its value therefore extends beyond simply detecting a protein.
In wound-repair studies, Keratin 14 expression provides a way to examine basal keratinocytes while the epithelium responds to injury. Researchers can use the marker to investigate how epithelial organization and keratinocyte activity relate to regeneration. This supports biological analysis of repair processes in which the tissue must restore an organized stratified epithelial structure.
KRT14 is relevant to epidermolysis bullosa simplex because mutations in this keratin can weaken the cellular structures that contribute to epithelial resilience. Examining KRT14 expression alongside the organization of epidermal cells helps researchers connect molecular changes with tissue-level effects. The marker therefore supports studies of how defects in keratin architecture relate to skin fragility.