Nano-newton Force Transducer
Nano-newton Force Transducer - Related Videos
10:25
Sub-nanometer Resolution Imaging with Amplitude-modulation Atomic Force Microscopy in Liquid
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Cited by 39 •
2016
We present a method for achieving sub-nanometer resolution images with amplitude-modulation (tapping mode) atomic force microscopy in liquid. The method is demonstrated on commercial atomic force microscopes. We explain the rationale behind our choices of parameters and suggest strategies for resolution optimization.
07:55
Isolating Myofibrils from Skeletal Muscle Biopsies and Determining Contractile Function with a Nano-Newton Resolution Force Transducer
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Cited by 1 •
2020
Presented here is a protocol to assess the contractile properties of striated muscle myofibrils with nano-Newton resolution. The protocol employs a setup with an interferometry-based, optical force probe. This setup generates data with a high signal-to-noise ratio and enables the assessment of the contractile kinetics of myofibrils.
10:12
Newton's Laws of Motion
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2023
Source: Andrew Duffy, PhD, Department of Physics, Boston University, Boston, MA This experiment examines at various situations involving two interacting objects. First, the experiment examines the forces that two objects apply to one another while they collide. The objects are wheeled carts that have variable masses. The purpose of this experiment is to discover when the force the first cart exerts on the other is the same magnitude as the force the second cart exerts back on the first, as well...
07:32
Newton's Law of Universal Gravitation
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2023
Source: Ketron Mitchell-Wynne, PhD, Asantha Cooray, PhD, Department of Physics & Astronomy, School of Physical Sciences, University of California, Irvine, CA Legend states that Isaac Newton saw an apple fall from a tree. He noticed the acceleration of the apple and deduced that there must have been a force acting upon the apple. He then surmised that if gravity can act at the top of the tree, it can also act at even larger distances. He observed the motion of the moon and the orbits of the...
08:00
Force and Acceleration
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2023
Source: Nicholas Timmons, Asantha Cooray, PhD, Department of Physics & Astronomy, School of Physical Sciences, University of California, Irvine, CA The goal of this experiment is to understand the components of force and their relation to motion through the use of Newton's second law by measuring the acceleration of a glider being acted upon by a force. Nearly every aspect of motion in everyday life can be described using Isaac Newton's three laws of motion. They describe how objects in...
FAQs
A force-induced deformation or displacement in the sensing element provides the physical response to the interaction. Calibration relates that response to the applied force, while the transducer converts the change into an electrical or optical signal. Researchers can then record and analyze the signal to quantify mechanical events that would otherwise be difficult to resolve.
Calibration establishes how a particular change in the sensing element corresponds to a force value. Without that relationship, deformation, displacement, or another physical response could be observed but not reliably quantified. In biological experiments, calibration supports meaningful comparisons among measurements of adhesion, tissue mechanics, molecular interactions, or forces generated by cells.
Electrical and optical readouts provide different ways to capture the physical response of the sensing element after force is applied. The selected signal can be recorded for later analysis, allowing researchers to translate a small mechanical change into quantitative data. This readout stage connects nanoscale force events with measurable biological behavior.
In biology, these devices can be applied to forces associated with cell adhesion, tissue mechanics, molecular interactions, and movement generated by motile cells or cytoskeletal structures. Examining these force-producing events helps researchers connect mechanical behavior with cellular function rather than studying biological activity only through chemical or structural observations.
A biological interaction first produces a measurable change in the calibrated sensing element, such as deformation or displacement. The device converts that change into an electrical or optical signal, which is recorded and analyzed. The resulting measurement provides a quantitative description of the force associated with the interaction and supports interpretation of its biological significance.
Researchers use them when biological forces are too small for conventional force sensors and when mechanical behavior is central to the question being studied. Applications include examining cell adhesion, tissue mechanics, molecular interactions, and force production by motile cells or cytoskeletal structures. These measurements support work in mechanobiology, biomaterials, disease mechanisms, and therapeutic development.