Near Field Signal

Near-field signals are short-range biological cues that act between neighboring cells or tissues, enabling local communication without affecting distant targets. They work when a signaling cell releases a soluble factor that diffuses a limited distance, or when membrane-bound molecules engage receptors through direct cell-cell contact; receptor binding then activates intracellular pathways that alter gene expression or cell behavior. This localized communication helps organize development, coordinate immune responses, guide tissue repair, and maintain tissue microenvironments. Studying near-field signals reveals how spatially restricted information shapes cell fate and provides insight into disease mechanisms, cell communication, and tissue engineering.

Near Field Signal - Related Videos

Research

JoVE Journal - Biology

Local Field Fluorescence Microscopy: Imaging Cellular Signals in Intact Hearts

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Cited by 8 •

2017

In the heart, molecular events coordinate the electrical and contractile function of the organ. A set of local field fluorescence microscopy techniques presented here enables the recording of cellular variables in intact hearts. Identifying mechanisms defining the cardiac function is critical in understanding how the heart works under pathological situations.

Wide-Field, Real-Time Imaging of Local and Systemic Wound Signals in Arabidopsis

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Cited by 7 •

2021

Extracellular glutamate-triggered systemic calcium signaling is critical for the induction of plant defense responses to mechanical wounding and herbivore attack in plants. This article describes a method to visualize the spatial and temporal dynamics of both these factors using Arabidopsis thaliana plants expressing calcium- and glutamate-sensitive fluorescent biosensors.

Education

JoVE Science Education - Physics

Electric Fields

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2023

Source: Yong P. Chen, PhD, Department of Physics & Astronomy, College of Science, Purdue University, West Lafayette, IN An electric field is generated by a charged object (referred to as the source charge) in the space around it, and represents the ability to exert electric force on another charged object (referred to as the test charge). Represented by a vector at any given point in the space, the electric field is the electrical force per unit test charge placed at that point (the force...

Magnetic Fields

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2023

Source: Yong P. Chen, PhD, Department of Physics & Astronomy, College of Science, Purdue University, West Lafayette, IN Magnetic fields can be generated by moving charges, such as an electrical current. The magnetic field generated by a current can be calculated from the Maxwell equation. In addition, magnetic objects such as bar magnets can also generate magnetic fields due to microscopic dynamics of charges inside the material. Magnetic fields will exert magnetic force on other moving...

Research

JoVE Journal - Environment
Free Sample

Microbial DNA Analysis in the Field Using a Biological Extraction Field Kit and a Field qPCR Unit

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2026

Reliable and accurate forms of field-deployable DNA analysis are crucial for many industries. This paper offers two methods for environmental microbial analysis in the field: 1) the isolation of microbial DNA from environmental samples using a biological extraction field kit, and 2) the analysis of DNA via the field qPCR unit.

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