Oncology

Oncology is the scientific and medical study of cancer, including how tumors arise, grow, spread, and respond to treatment. Cancer develops when genetic and epigenetic changes disrupt controls on cell division, survival, tissue invasion, and metastasis, while interactions with the tumor microenvironment can further support disease progression. In biology, oncology applies molecular analysis, pathology, imaging, and clinical studies to classify tumors and guide prevention, diagnosis, prognosis, and therapy. Research in this field has advanced targeted treatments, immunotherapy, and precision medicine, improving understanding of tumor biology and enabling more individualized cancer care.

Oncology - Related Videos

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JoVE Journal - Medicine
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Generation of Comprehensive Thoracic Oncology Database - Tool for Translational Research

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Cited by 5 •

2011

A thoracic oncology database was developed to serve as a comprehensive repository for clinical and laboratory data for the purposes of translational research. The database will serve translational cancer researchers within the Thoracic Oncology Research Program. This database is adaptable to other cancer models, as well as other human diseases.

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JoVE Journal - Medicine
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Multispectral Real-time Fluorescence Imaging for Intraoperative Detection of the Sentinel Lymph Node in Gynecologic Oncology

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Cited by 41 •

2010

Fluorescence imaging is a promising innovative modality for image-guided surgery in surgical oncology. In this video we describe the technical procedure for detection of the sentinel lymph node using fluorescence imaging as showcased in gynecologic oncologicy. A multispectral fluorescence camera system, together with the fluorescent agent indocyanine green, is applied.

Research

JoVE Journal - Cancer Research

A Human Peripheral Blood Mononuclear Cell (PBMC) Engrafted Humanized Xenograft Model for Translational Immuno-oncology (I-O) Research

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Cited by 6 •

2019

We describe a human peripheral blood mononuclear cell (PBMC) — based humanized xenograft mouse model for translational immuno-oncology research. This protocol could serve as a general guideline for establishing and characterizing similar models for I-O therapy assessment.

Automated Multiplex Immunofluorescence Panel for Immuno-oncology Studies on Formalin-fixed Carcinoma Tissue Specimens

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Cited by 37 •

2019

A detailed protocol for a six-marker multiplex immunofluorescence panel is optimized and performed, using an automated stainer for more consistent results and a shorter procedure time. This approach can be directly adapted by any laboratory for immuno-oncology studies.

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JoVE Journal - Medicine
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Dynamic Lung Tumor Tracking for Stereotactic Ablative Body Radiation Therapy

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Cited by 9 •

2015

Stereotactic ablative body radiation therapy (SBRT) involves the precise delivery of high-dose radiation to cancer tumor targets. A novel SBRT platform offers a first-of-its-kind gimbaled radiation accelerator mounted within a pivoting O-ring gantry capable of dynamic image-guided tumor tracking. Here, we describe dynamic tumor tracking for lung targets.

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