Oncostatin M
Oncostatin M - Related Videos
10:50
Molecular Modulation by Lentivirus-Delivered Specific shRNAs in Endoplasmic Reticulum Stressed Neurons
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Cited by 1 •
2021
In the present study, the expression is knocked down of two downstream signaling components of the PERK pathway, the cytoprotective calcineurin and the pro-apoptotic CHOP, by using specific shRNAs. In opposite ways, these modulate the susceptibility of primary cortical neurons to neurite atrophy after induction of endoplasmic reticulum stress.
09:28
A Microfluidic Device for Quantifying Bacterial Chemotaxis in Stable Concentration Gradients
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Cited by 7 •
2010
This protocol describes the development of a microfluidic device for investigating bacterial chemotaxis in stable concentration gradients of chemoeffectors.
07:21
Automated Interactive Video Playback for Studies of Animal Communication
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Cited by 23 •
2011
Video playback is a widely used technique in animal behavior. We created and evaluated a program that applies rules-based, interactive playback of 3-D computer animations in response to real-time, automated data on subject behavior.
15:06
Synthesis of an Intein-mediated Artificial Protein Hydrogel
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Cited by 2 •
2014
We present the synthesis of a split-intein-mediated protein hydrogel. The building blocks of this hydrogel are two protein copolymers each containing a subunit of a trimeric protein that serves as a crosslinker and one half of a split intein. Mixing of the two protein copolymers triggers an intein trans-splicing reaction, yielding a polypeptide unit that self-assembles into a hydrogel. This hydrogel is highly pH- and temperature-stable, compatible with organic solvents, and easily incorporates...
09:02
Rapid PCR Thermocycling using Microscale Thermal Convection
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Cited by 21 •
2011
We describe a novel method to perform DNA replication via the polymerase chain reaction (PCR). Thermal convection is harnessed to continuously shuttle reagents between denaturing, annealing, and extension conditions by maintaining opposing surfaces of the reactor at constant temperature. This inherently simple design promises to make rapid PCR more accessible.
FAQs
The receptor partner helps determine how cells interpret OSM signaling. OSM binds complexes that include gp130 together with either OSMR or LIFR, creating a route into intracellular signaling. Because these complexes are not identical, examining which receptor combination is present can help explain why OSM produces different cellular responses in different biological settings.
Once receptor binding occurs, OSM can engage JAK/STAT, MAPK, and PI3K pathways. These pathways transmit the extracellular signal through intracellular steps that ultimately alter gene expression, cell growth, differentiation, or tissue behavior. Considering the pathways together is important because OSM responses reflect coordinated signaling rather than a single isolated molecular event.
The outcome depends on the responding cell and tissue setting. OSM can act across immune, stromal, and epithelial compartments, where signaling may produce different changes in growth, differentiation, inflammation, or remodeling. The same cytokine can therefore participate in repair in one setting and disease-associated remodeling in another, preventing assignment of one universal effect.
OSM links communication among immune, stromal, and epithelial cells with larger tissue-level changes. By changing gene expression and cellular behavior, its signaling can influence growth, differentiation, inflammation, and remodeling. This makes OSM relevant not only to individual-cell studies but also to explaining coordinated responses during wound repair and chronic inflammatory disease.
In hematopoiesis and wound repair, OSM provides a model for studying how signals from one cell population influence others. Its activity can be considered across immune, stromal, and epithelial compartments, then related to changes in growth, differentiation, and tissue remodeling. This approach helps connect molecular signaling with coordinated biological outcomes during regeneration and blood-cell development.
OSM signaling is relevant because it connects inflammatory communication with changes in cellular behavior and tissue structure. In chronic inflammatory disease, persistent or misdirected signaling could be examined in relation to remodeling rather than inflammation alone. Studying these linked effects helps clarify how immune, stromal, and epithelial responses contribute to sustained tissue-level pathology.
These settings are important because OSM has context-dependent effects in tumors, fibrotic tissues, and vascular cells. Researchers can ask whether its signaling corresponds to local changes in growth, differentiation, inflammation, or remodeling in each setting. Comparing these contexts is useful because an effect observed in one tissue may not predict the outcome in another.
OSM may be useful in these roles because its signaling is connected to disease-relevant processes, including inflammation, tissue remodeling, and altered cellular behavior. As a biomarker, it could help indicate a biological state; as a therapeutic target, its receptor-linked pathways could provide a point for intervention. Its context dependence remains essential when interpreting either use.