Polymer Spots
Polymer Spots - Related Videos
02:34
Polymers
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2020
The word polymer is derived from the Greek words “poly” which means “many” and “mer” which means “parts”. Polymers are long chains of molecules composed of repeating units of smaller molecules, known as monomers. They either occur naturally, such as DNA and proteins, or can be constructed synthetically, like plastics. They have varied structural characteristics, such as linear chains, branched chains, or complex networks, that contribute to the properties that they exhibit. Additionally,...
13:37
Polymer Microarrays for High Throughput Discovery of Biomaterials
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Cited by 33 •
2012
A description of the formation of a polymer microarray using an on-chip photopolymerization technique. The high throughput surface characterization using atomic force microscopy, water contact angle measurements, X-ray photoelectron spectroscopy and time of flight secondary ion mass spectrometry and a cell attachment assay is also described.
10:27
Preparation of Highly Porous Coordination Polymer Coatings on Macroporous Polymer Monoliths for Enhanced Enrichment of Phosphopeptides
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Cited by 12 •
2015
A procedure for the preparation of porous hybrid separation media composed of a macroporous polymer monolith internally coated by a high surface area microporous coordination polymer is presented.
02:49
High-Throughput Identification of Bacteria-Repellent Polymers via Microarray Screening
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2025
Source: Venkateswaran, S., et al. High-throughput Identification of Bacteria Repellent Polymers for Medical Devices. J. Vis. Exp. (2016)This video demonstrates a high-throughput method to identify bacteria-repellent polymers using a microarray slide exposed to mixed bacterial cultures. Bacterial binding is assessed by DAPI fluorescence, where reduced signal indicates polymers with minimal surface attachment.
10:45
Finding Your Blind Spot and Perceptual Filling-in
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2023
Source: Laboratory of Jonathan Flombaum—Johns Hopkins University In the back of everyone's eye is a small piece of neural tissue called the retina. The retina has photosensitive cells that respond to stimulation by light. The responses of these cells are sent into the brain through the optic nerve, a bundle of neural fibers. In each retina there is a place somewhere in the periphery where the outputs from retinal cells collect and the bundled optic nerve exits to the brain. At that location,...
FAQs
Stability develops after a polymer solution or melt is placed at a selected surface position and the deposited material undergoes solvent evaporation or curing. These post-deposition processes convert the initially applied material into a persistent spot. Controlling the deposited location and the stabilization step helps produce patterns with defined dimensions, composition, and surface chemistry.
Spot size, composition, and surface chemistry determine which features a patterned surface presents to its surroundings. In biological experiments, these variables can influence where cells attach or which proteins and nucleic acids remain immobilized. Adjusting them allows investigators to compare localized chemical or physical conditions across a surface rather than relying on one uniform interface.
Their localized surface chemistry can provide defined regions for immobilizing proteins or nucleic acids, while their physical and chemical patterning can organize cell attachment. This separation of functions across a surface is useful when researchers need to examine how cells or biomolecular targets respond to particular material environments. It connects material design with biological activity.
Preparation begins by selecting positions on a surface, then depositing a polymer solution or melt at those locations. The deposited material is allowed to undergo solvent evaporation or curing, producing stable spots. Researchers can vary the deposited material and the placement pattern to create surfaces with different spot sizes, compositions, and surface chemistries for biological testing.
Arranging many defined regions on one surface creates a format for examining multiple localized conditions in parallel. Each spot can present a chosen polymer composition or surface chemistry, allowing cellular responses, protein immobilization, or nucleic-acid interactions to be assessed across a patterned material. This parallel organization supports high-throughput comparisons across defined biological interfaces.
In biology, these patterns support studies of cell-material interactions and the design of biosensors, diagnostic platforms, and tissue-engineering scaffolds. They can also create interfaces that regulate biological activity by positioning relevant chemical, physical, or biological features. The application depends on whether the goal is to organize cells, immobilize biomolecules, or analyze responses across defined regions.