Skin Cancer Pathways
Skin Cancer Pathways - Related Videos
01:30
Skin Cancer
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2023
Skin cancer is a type of cancer that occurs when there is an abnormal growth of skin cells, usually triggered by damage to the DNA within the skin cells. It is primarily caused by exposure to ultraviolet (UV) radiation from the sun or artificial sources like tanning beds. Skin cancer is the most common type of cancer worldwide, and its incidence continues to rise. Basal Cell Carcinoma (BCC): BCC is the most common type of skin cancer, accounting for about 80% of cases. It typically develops in...
03:02
Chemical-induced Two-stage Skin Carcinogenesis Model: An Experimental In Vivo Mouse Model of Skin Cancer
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2023
This video describes the procedure to induce two-stage skin carcinogenesis to study tumor initiation by topical application of chemicals. In the first step, a mutagen, DMBA, is applied onto the skin of a mouse model which initiates tumor formation by causing mutations in the stem cells, followed by the application of a growth stimulator, TPA, which accelerates skin papilloma formation.
06:08
Quantitative Visualization and Detection of Skin Cancer Using Dynamic Thermal Imaging
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Cited by 69 •
2011
We demonstrated that malignant pigmented lesions with increased metabolic activity generate quantifiable amounts of heat and the measurement of the transient thermal response of the skin to a cooling excitation allows quantitative identification of melanoma and other skin cancers (vs. non-proliferative nevi) at an early stage of the disease.
06:53
Cell Population Analyses During Skin Carcinogenesis
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Cited by 6 •
2013
Carcinogenesis is a process involving interactions between cancer cells and the cancer microenvironment. To dissect the molecular events, one needs to isolate different cell populations at different stages during cancer development. Using a mouse model for basal cell carcinoma, we describe a protocol for cell analyses during carcinogenesis.
07:59
Murine Full-thickness Skin Transplantation
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Cited by 41 •
2017
Murine full-thickness skin transplantation is a well-established model to study rejection in an alloimmune setting. Here, we provide a tutorial of each step involved in performing a BALB/c-->C57BL/6 full-thickness skin transplant.
FAQs
Mutations can activate pathway components continuously, while epigenetic changes can modify gene activity without changing the DNA sequence. These alterations may maintain proliferation signals, weaken responses that normally limit cell survival, or change differentiation programs. The resulting imbalance helps explain how skin cells acquire malignant behaviors and why tumors can differ in their molecular characteristics.
These networks regulate overlapping but distinct cellular functions, including growth, survival, tissue development, and differentiation. Examining them together can reveal how multiple signaling abnormalities contribute to melanoma and nonmelanoma skin cancers. Their combined analysis also helps researchers compare pathway activity across tumor subtypes rather than attributing every cancer behavior to a single molecular route.
The tumor microenvironment can modify how malignant cells respond to surrounding conditions and signals. In skin cancer, pathway disruption may therefore produce effects that depend on interactions between tumor cells and their local environment, including changes in invasion or treatment response. Studying these relationships gives a broader view of progression than analyzing cancer-cell signaling in isolation.
Researchers compare the activity or alteration of signaling networks across melanoma and nonmelanoma skin cancers and among their subtypes. This approach can identify shared pathway features as well as subtype-specific patterns. The comparisons support molecular classification and may indicate which tumors are more likely to show particular biological behaviors or respond differently to targeted treatment strategies.
Pathway analysis can reveal molecular changes associated with tumor behavior, subtype, or treatment response. These changes may serve as biomarkers, which are measurable biological features used to characterize disease or predict an outcome. By connecting pathway alterations with clinical or experimental patterns, researchers can prioritize markers for studying melanoma and nonmelanoma skin cancers.
A tumor may continue growing when pathway changes preserve proliferation or survival signals despite treatment aimed at a particular molecular target. Examining several networks can expose alternative or compensatory signaling patterns linked to resistance. This information helps researchers investigate why responses differ between tumors and identify pathway relationships that could guide improved treatment strategies.