Cis Trans Configuration
Cis Trans Configuration - Related Videos
02:37
Disubstituted Cyclohexanes: cis-trans Isomerism
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2023
Depending upon the different spatial orientation of the substituents, the disubstituted cycloalkanes exhibit two types of stereoisomers. The cis isomers have the substituents on the same side of the ring, whereas the trans isomers have the substituents on the opposite sides. These stereoisomers exhibit different physical properties and cannot be interconverted without breaking the carbon-carbon bonds. In cyclohexane, the substituents can occupy different positions generating distinct isomers.
02:02
Cis-regulatory Sequences
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2020
Cis-regulatory sequences are short fragments of non-coding DNA that are present on the same chromosomes as the genes that they regulate. These fragments serve as binding sites for transcriptional regulators, proteins that are responsible for controlling gene transcription and differential gene expression across cell types in eukaryotes. Cis-regulatory sequences can be close to the gene of interest or thousands of bases away in the DNA sequence; however, those sequences that are further away are...
05:48
Cell Aggregation Assays to Evaluate the Binding of the Drosophila Notch with Trans-Ligands and its Inhibition by Cis-Ligands
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Cited by 3 •
2018
Complexity of in vivo systems makes it difficult to distinguish between the activation and inhibition of Notch receptor by trans- and cis-ligands, respectively. Here, we present a protocol based on in vitro cell-aggregation assays for qualitative and semi-quantitative evaluation of the binding of Drosophila Notch to trans-ligands vs cis-ligands.
02:46
Electron Configurations
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2023
Electron configurations and orbital diagrams can be determined by applying the Aufbau principle (each added electron occupies the subshell of lowest energy available), Pauli exclusion principle (no two electrons can have the same set of four quantum numbers), and Hund’s rule of maximum multiplicity (whenever possible, electrons retain unpaired spins in degenerate orbitals). The relative energies of the subshells determine the order in which atomic orbitals are filled (1s, 2s, 2p, 3s, 3p, 4s,...
01:22
Controller Configurations
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2024
Controller configurations are crucial in a car's cruise control system because they manage speed over time to maintain a consistent pace regardless of road conditions, thereby meeting design goals. In traditional control systems, fixed-configuration design involves predetermined controller placement. System performance modifications are known as compensation. Control-system compensation involves various configurations, most commonly series or cascade compensation, in which the controller aligns...
FAQs
Cis-trans configuration persists because a rigid structural feature limits rotation between alternative arrangements. Around a carbon-carbon double bond or within a ring, changing from one arrangement to the other cannot occur through ordinary free rotation. This restricted motion allows the alternatives to remain distinguishable, which is why they can be analyzed as separate stereochemical forms.
To identify cis-trans configuration in a structural drawing, first locate the double bond or ring that restricts motion. Then compare the positions of the relevant comparable groups on the two sides of that feature. A same-side relationship indicates the cis arrangement, whereas an opposite-side relationship indicates the trans arrangement, provided the comparison is chemically appropriate.
The relative arrangement can change molecular shape and polarity, so cis and trans forms may show different physical behavior. Those differences can appear in properties such as boiling point and in how a molecule functions biologically. Consequently, configuration is useful when explaining why stereoisomers with the same connectivity do not always behave identically.
Unlike a structure with freely rotating bonds, a cis-trans system retains distinguishable positional arrangements because its rigid feature blocks easy interconversion. If that restriction were absent, different placements could change through rotation instead of remaining separate forms. This comparison explains why rigidity is essential for observing cis and trans alternatives as meaningful stereochemical outcomes.
To assign cis-trans configuration, examine a molecular structure in a consistent orientation, identify the rigid bond or ring, and mark the relevant groups attached around it. Compare their relative sides rather than judging the molecule's overall three-dimensional appearance. This approach supports consistent identification of isomers and helps distinguish structures that differ only in stereochemical arrangement.
Chemists use cis-trans configuration to distinguish reaction products and interpret molecular structures. The assignment also supports predictions about physical properties, including boiling point, and helps relate molecular arrangement to biological activity. In materials, pharmaceuticals, and natural compounds, recognizing the configuration provides a stereochemical context for comparing molecules and their observed behavior.