Radiation Weighting Factor

Radiation weighting factor is a dimensionless value used in radiation protection to account for the differing biological effects of ionizing radiation at the same absorbed dose. It is applied by multiplying absorbed dose in gray by the factor assigned to the radiation type and energy, producing equivalent dose in sieverts; values reflect relative biological effectiveness, including the radiation’s ability to cause dense ionization and DNA damage. In chemistry, this concept supports the safe handling of radionuclides and interpretation of radiochemical experiments, helping researchers compare exposures, design shielding, assess risk, and communicate dose limits for alpha, beta, gamma, neutron, and proton radiation.

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Education

JoVE Core - Chemistry

Biological Effects of Radiation

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2020

All radioactive nuclides emit high-energy particles or electromagnetic waves. When this radiation encounters living cells, it can cause heating, break chemical bonds, or ionize molecules. The most serious biological damage results when these radioactive emissions fragment or ionize molecules. For example, α and β particles emitted from nuclear decay reactions possess much higher energies than ordinary chemical bond energies. When these particles strike and penetrate matter, they produce ions...

Research

JoVE Journal - Medicine
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Dynamic Lung Tumor Tracking for Stereotactic Ablative Body Radiation Therapy

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Cited by 9 •

2015

Stereotactic ablative body radiation therapy (SBRT) involves the precise delivery of high-dose radiation to cancer tumor targets. A novel SBRT platform offers a first-of-its-kind gimbaled radiation accelerator mounted within a pivoting O-ring gantry capable of dynamic image-guided tumor tracking. Here, we describe dynamic tumor tracking for lung targets.

Weighted Mean

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2023

While taking the arithmetic, geometric, or harmonic mean of a sample data set, equal importance is assigned to all the data points. However, all the values may not always be equally important in some data sets. An intrinsic bias might make it more important to give more weightage to specific values over others. For example, consider the number of goals scored in the matches of a tournament. While computing the average number of goals scored in the tournament, it may be more important to...

Radiation: Applications

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2023

The average temperature of Earth is the subject of much current discussion. Earth is in radiative contact with both the Sun and dark space; it receives almost all its energy from the radiation of the Sun and reflects some of it into outer space. Dark space is very cold, about 3 K, so Earth radiates energy into it. For instance, heat transfer occurs from soil and grasses, the rate of which can be so rapid that frost can occur on clear summer evenings, even in warm latitudes. The average...

Quantification of γH2AX Foci in Response to Ionising Radiation

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Cited by 23 •

2010

Quantification of DNA double-strand streaks using γH2AX formation as a molecular marker has become an invaluable tool in radiation biology. Here we demonstrate the use of an immunofluorescence assay for quantification of γH2AX foci after exposure of cells to radiation.

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