Nebulizers
Nebulizers - Related Videos
07:28
Dry Powder and Nebulized Aerosol Inhalation of Pharmaceuticals Delivered to Mice Using a Nose-only Exposure System
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Cited by 11 •
2017
The inhalation unit described herein can generate, sample for characterization, and uniformly deposit a drug aerosol in the lungs of rodents. This enables the pre-clinical determination of the efficacy and safety of drug doses deposited in the lungs; key data enabling clinical inhaled drug development.
02:46
A Mouse Model of Pulmonary Fibrosis Induced by Nasal Bleomycin Nebulization
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Cited by 4 •
2023
Various animal models of pulmonary fibrosis have been established using bleomycin to clarify the pathogenesis of pulmonary fibrosis and find new drug targets. However, most pulmonary fibrosis models targeting lung tissue have uneven drug administration. Here, we propose a model of uniform pulmonary fibrosis induced by nasal bleomycin nebulization.
02:55
Aerosol Delivery of Mycobacterium tuberculosis for Pulmonary Infection in a Mouse Model
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2026
Source: Mueller, A., et al. An Experimental Model to Study Tuberculosis-Malaria Coinfection upon Natural Transmission of Mycobacterium tuberculosis and Plasmodium berghei. J. Vis. Exp. (2014)This video demonstrates the aerosol delivery of Mycobacterium tuberculosis (Mtb) to mice using a nebulizer-based chamber system to induce pulmonary infection, providing a controlled and reproducible model for studying airborne tuberculosis transmission and host-pathogen interactions in vivo.
04:30
A Technique to Generate and Deliver Drug Aerosols Directly to Mouse Lungs
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2025
This video demonstrates the generation of drug aerosols and the targeted nose-only delivery of these aerosols to mice using an inhalation unit equipped with an aerosol generator. The mouse is restrained in a nose-only restrainer and connected to the inhalation unit, which delivers the drug directly into the mouse's nasal cavity. Subsequently, the drug passes through the trachea and enters the lungs.
08:33
A Method for Generating Pulmonary Neutrophilia Using Aerosolized Lipopolysaccharide
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Cited by 10 •
2014
We describe a method for inducing neutrophilic pulmonary inflammation by challenge to aerosolized lipopolysaccharide by nebulization, to model acute lung injury. In addition, basic surgical techniques for lung isolation, tracheal intubation and bronchoalveolar lavage are also described.
FAQs
Compressed-air models use airflow, whereas ultrasonic versions rely on ultrasonic vibrations and vibrating-mesh models use a moving mesh to break liquid into aerosol droplets. These mechanisms represent different device designs for the same delivery goal, and the design can influence how treatment is produced and administered. Understanding the mechanism helps relate device operation to medication delivery and patient inhalation needs.
Aerosol droplet size can affect how effectively medication reaches the respiratory tract, while the patient’s breathing pattern influences inhalation during treatment. These factors work alongside device design rather than independently. Consequently, suitable aerosol production is not sufficient by itself; consistent breathing and appropriate droplet characteristics both contribute to whether the intended medication delivery is achieved.
Drug formulation matters because nebulizers must convert a liquid preparation into inhalable droplets. Medications used this way, including bronchodilators, corticosteroids, antibiotics, and saline, therefore depend on a suitable liquid formulation for aerosol delivery. Formulation is one reason treatment effectiveness cannot be judged from the device alone; the medication preparation and aerosol-generation process must work together.
A clinical session generally involves placing the selected liquid medication in the nebulizer, positioning a mouthpiece or mask, and having the patient inhale during normal breathing. The device then generates the aerosol while the patient breathes it into the respiratory tract. This workflow can support medication delivery without requiring the coordinated inhalation maneuver associated with some inhaler use.
The main clinical advantage described is usability for patients who have difficulty coordinating inhalation with a metered-dose inhaler. Nebulizer treatment allows medication to be inhaled through a mouthpiece or mask during normal breathing, so it may be particularly practical when coordinating inhalation with the inhaler is challenging. Choice still depends on treatment needs and device-related factors.
In clinical care, nebulizers may administer bronchodilators, corticosteroids, antibiotics, or saline. The relevant conditions include asthma, chronic obstructive pulmonary disease, and respiratory infections. This range shows that nebulizers serve as a delivery route for multiple therapeutic categories rather than being limited to one diagnosis or one medication class.
Maintenance is one of the factors that can affect how effectively a nebulizer delivers medication, alongside droplet size, drug formulation, and breathing pattern. It therefore belongs within the overall treatment process rather than being treated as separate from clinical performance. Attention to maintenance helps clinicians interpret treatment effectiveness in the context of both device condition and inhalation factors.