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Dry Powder and Nebulized Aerosol Inhalation of Pharmaceuticals Delivered to Mice Using a Nose-only Exposure System
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Medicine
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JoVE Journal Medicine
Dry Powder and Nebulized Aerosol Inhalation of Pharmaceuticals Delivered to Mice Using a Nose-only Exposure System

Dry Powder and Nebulized Aerosol Inhalation of Pharmaceuticals Delivered to Mice Using a Nose-only Exposure System

DOI:
10.3791/55454-v

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07:28 min

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April 06, 2017

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, ,
1Inflammation Research,Amgen

Chapters

  • 00:05Title
  • 00:57Dry Powder and Nebulized Liquid Aerosol Generation
  • 02:46Aerosol Exposure Experimental Setup and Delivery
  • 05:28Results: Representative Effects of Real Time Aerosol Delivery
  • 06:51Conclusion

Summary

Automatic Translation

Automatic Translation

The inhalation unit described herein can generate, sample for characterization, and uniformly deposit a drug aerosol in the lungs of rodents. This enables the pre-clinical determination of the efficacy and safety of drug doses deposited in the lungs; key data enabling clinical inhaled drug development.

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Keywords: Dry PowderNebulized AerosolInhalationPharmaceuticalsMiceNose-only Exposure SystemAerosol GenerationJet MillMicronized ParticlesWright Dust FeedDry Powder Aerosol GeneratorNebulized Liquid AerosolSyringe PumpJet NebulizerPre-separatorAbsolute Filter Holder

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