Termination Phase
Termination Phase - Related Videos
01:44
Termination of Translation
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2020
The large ribosomal subunit has several important structures essential to translation. These include the peptidyl transferase center (PTC) - which is the site where the peptide bond is formed - and a large, internal, water-filled tube through which the nascent polypeptide moves. This latter structure is called the Peptide Exit Tunnel, and it begins at the PTC and spans the body of the large ribosomal subunit. During translation, as the nascent polypeptide chain is synthesized, it passes through...
08:26
Comparative Analysis of Lower Limb Kinematics between the Initial and Terminal Phase of 5km Treadmill Running
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Cited by 3 •
2020
This study investigated the biomechanical characteristics of the lower extremity kinematic variables between the initial and terminal phase of 5 km treadmill running. The lower-limb kinematic data of 10 runners were collected using a three-dimensional motion capture system on a treadmill at the initial phase (0.5 km) and the terminal phase (5 km), respectively.
10:50
Single Phase Transformers
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2023
Source: Ali Bazzi, Department of Electrical Engineering, University of Connecticut, Storrs, CT. Transformers are stationary electric machines that step up or down AC voltage. They are typically formed of primary and secondary coils or windings, where the voltage on the primary is stepped up or down at the secondary, or the other way around. When a voltage is applied to one of the windings and current flows in that winding, flux is induced in the magnetic core, coupling both windings. With an AC...
15:16
Loading Drosophila Nerve Terminals with Calcium Indicators
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Cited by 17 •
2007
Calcium is a ubiquitous messenger in the nervous system, essential for triggering neurotransmitter release and changes in synaptic strength. Here we demonstrate a technique for loading Ca2+-indicators into Drosophila nerve terminals. We also demonstrate fabrication of the required apparatus and emphasize points critical for the technique's success.
11:15
Single Phase Rectifiers
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2023
Source: Ali Bazzi, Department of Electrical Engineering, University of Connecticut, Storrs, CT. A DC power supply is generally considered to be a device that supplies DC, or unidirectional, voltage and current. Batteries are one such power supply, however, they are limited in terms of lifetime and expense. An alternative method to providing unidirectional power is to transform AC line power to DC power using a rectifier. A rectifier is a device that passes current in one direction, and blocks...
FAQs
Data integrity depends on closing the links between participant information, study conduct, and the final analysis. During the Termination Phase, teams resolve outstanding data queries and verify that records are complete, so unresolved inconsistencies do not remain hidden in the study file. This creates a more reliable basis for final analysis and reporting while preserving an auditable account of the study’s conclusion.
Protocol deviations show where the study’s actual conduct differed from what the protocol planned. Recording them during termination preserves this context for final review rather than leaving unexplained gaps in the record. The documentation helps investigators and sponsors understand the completed study, supports transparent interpretation of its data, and contributes to an auditable record for applicable ethical and regulatory obligations.
Accounting for investigational materials confirms that the research team has addressed the materials associated with the completed study. This step is important because an unverified material record can leave the closure documentation incomplete. Reviewing material accountability alongside participant follow-up, data queries, and study records gives sponsors and investigators a more coherent picture of how the study concluded and supports orderly formal closure.
They should verify that planned participant follow-up is complete, outstanding data queries are resolved, investigational materials are accounted for, protocol deviations are documented, and records are complete. Reviewing these elements together helps the team identify unfinished work before final analysis and reporting, protects participant safety and confidentiality, and leaves a defensible record of the study’s close.
Completing follow-up ensures that planned participant-related information is not left unfinished as the study closes. At the same time, reviewing records with attention to confidentiality helps ensure that closure does not compromise participant information. These safeguards connect operational completion with ethical responsibility, making termination more than an administrative endpoint and supporting a properly documented conclusion.
The closure record brings together documented protocol deviations, resolved data issues, participant follow-up status, material accountability, and record-completeness checks. Reviewing this information can show where planning, conduct, or closure processes need improvement. Sponsors and research teams can use these lessons to strengthen future trials while retaining evidence of what occurred and demonstrating attention to applicable ethical and regulatory obligations.