Polycystic Ovary Syndrome Model
Polycystic Ovary Syndrome Model - Related Videos
08:20
A Hyperandrogenic Mouse Model to Study Polycystic Ovary Syndrome
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Cited by 20 •
2018
We describe the development of a lean PCOS-like mouse model with dihydrotestosterone pellet to study the pathophysiology of PCOS and the offspring from these PCOS-like dams.
09:44
Evaluation of Hepatic Glucose Production in a Polycystic Ovary Syndrome Mouse Model
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2022
This study describes the direct measurement of hepatic glucose production in a polycystic ovary syndrome mouse model by using a stable isotopic glucose tracer via tail vein in both fasting and glucose-rich states in tandem.
04:49
A Modified Technique for Inducing Polycystic Ovary Syndrome in Mice
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Cited by 1 •
2024
This protocol introduces a technique for inducing polycystic ovary syndrome (PCOS) models in mice through controlled letrozole release using mini-pumps. Under adequate anesthesia, the mini-pump was implanted subcutaneously, and PCOS was successfully induced in the mice after a certain period of the mini-pump release.
03:53
Subcutaneous Dihydrotestosterone (DHT) Treatment: Mouse Model of Polycystic Ovary Syndrome (PCOS)
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2023
This article describes a way to prepare and insert dihydrotestosterone (DHT) pellets to model Polycystic Ovary Syndrome (PCOS) in mice. The example protocol demonstrates the procedure in mice used for reproductive and metabolic studies.
04:02
Intact Ovary Harvest from Mouse: A Surgical Procedure to Isolate Complete Ovary from Murine Model
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2025
In this video, we describe a surgical procedure to harvest intact ovary from a mouse model.
FAQs
These conditions can disrupt follicle development, hormone production, and ovulatory cycles, allowing researchers to examine how endocrine and metabolic disturbances influence reproductive physiology. Using androgen exposure or altered insulin signaling helps separate or compare contributing mechanisms rather than treating PCOS as a single pathway. The resulting changes can be studied in relation to ovarian function and fertility-related outcomes.
Researchers can investigate interactions among follicle development, ovarian hormone production, and ovulatory cycling. These processes are especially useful for developmental biology because they connect cellular and tissue-level changes with reproductive physiology. Depending on the selected system, the model can also help examine how genetic, hormonal, or environmental factors alter ovarian development and contribute to PCOS-associated reproductive features.
Cultured cells, organoids, and animals represent different levels of ovarian organization, so each can reveal different aspects of the condition. Cell-based systems support focused study of responses to hormonal or metabolic conditions, whereas organoids and animals provide broader contexts for ovarian development or reproductive physiology. Comparing systems can clarify which findings are specific to a model and which reflect wider biological effects.
Selection depends on the biological question and the feature being examined. A cultured-cell system may suit focused analysis of hormone production, while an organoid or animal system may better support investigation of follicle development, ovarian development, or ovulatory cycles. Researchers also choose whether to examine androgen exposure, altered insulin signaling, or broader genetic, hormonal, and environmental influences.
A study generally selects a cultured cell, organoid, or animal system, applies a relevant condition such as excess androgen or altered insulin signaling, and then evaluates changes in ovarian or reproductive features. Measurements may focus on follicle development, hormone production, and ovulatory cycles. This workflow connects the imposed condition with specific developmental or physiological outcomes.
These systems support evaluation of therapeutic strategies by showing whether an intervention changes PCOS-associated reproductive, endocrine, or metabolic features. Researchers can examine effects on follicle development, hormone production, or ovulatory cycles, depending on the model. Such comparisons help identify whether a strategy influences a selected disease mechanism and whether it improves outcomes relevant to fertility or ovarian function.