Hindbrain Ventricle
Hindbrain Ventricle - Related Videos
06:17
Manual Drainage of the Zebrafish Embryonic Brain Ventricles
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Cited by 9 •
2012
We present a method to collect cerebrospinal fluid (CSF) and to create a system which lacks CSF within the embryonic zebrafish brain ventricular system. This allows for further examination of CSF composition and its requirement during embryonic brain development.
08:28
Zebrafish Brain Ventricle Injection
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Cited by 72 •
2009
After neural tube formation, the neuroepithelium constricts and folds while the tube fills with embryonic cerebrospinal fluid (eCSF) to form the embryonic brain ventricles. We developed this ventricle injection technique to better visualize the fluid filled space in contrast to the neuroepithelial shape in a live embryo.
10:57
Mouse Hindbrain Ex Vivo Culture to Study Facial Branchiomotor Neuron Migration
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Cited by 4 •
2014
Embryonic neurons are born in the ventricular zone of the neural tube, but migrate to reach appropriate targets. Facial branchiomotor (FBM) neurons are a useful model to study neuronal migration. This protocol describes the wholemount ex vivo culture of mouse embryo hindbrains to investigate mechanisms that regulate FBM migration.
09:17
Labeling and Imaging Cells in the Zebrafish Hindbrain
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Cited by 7 •
2010
Key to understanding the morphogenetic processes that shape the early embryo is the ability to image cells at high resolution. We describe here a technique for labeling single cells or small clusters of cells in whole zebrafish embryos with membrane-targeted Green Fluorescent Protein.
01:18
Anatomy of the Brain: Ventricles
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2025
There are hollow fluid-filled cavities known as ventricles deep inside the human brain. There are two lateral ventricles, one in each cerebral hemisphere, and each has three different projections — the anterior, inferior, and posterior horns visible from the lateral side. A thin membrane called the septum pellucidum separates the two lateral ventricles. The slender third ventricle in the diencephalon is connected to each lateral ventricle via a channel called the interventricular foramen. The...
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The median and lateral apertures provide exit routes from the hindbrain ventricle into the subarachnoid space, allowing cerebrospinal fluid to continue toward the spinal canal. Because this circulation connects the ventricular cavity with surrounding central nervous system spaces, disruption at these openings can impair fluid movement and contribute to hydrocephalus.
Inflammation in or around the hindbrain ventricle can affect both the brainstem region and cerebrospinal fluid pathways. This makes the compartment useful for examining how inflammatory mediators and immune responses alter the central nervous system environment during infection, particularly when inflammation interferes with normal fluid circulation.
Obstruction primarily threatens cerebrospinal fluid movement through the ventricular pathway, whereas inflammation can alter the surrounding central nervous system environment and contribute to ventriculitis. These processes may occur together, but distinguishing impaired flow from inflammatory involvement helps researchers interpret whether hydrocephalus, infection-related irritation, or both are affecting the hindbrain region.
The compartment provides a relevant setting for studying interactions among pathogens, cerebrospinal fluid, and immune responses near the brainstem. Because fluid passes through the ventricle and onward into surrounding spaces, investigators can consider how infection-related changes may influence connected pathways rather than treating the brainstem region as an isolated site.
Investigating the pathway can clarify how infection or inflammation relates to cerebrospinal fluid circulation, brainstem involvement, and complications such as ventriculitis or hydrocephalus. The emphasis is not only on the cavity itself, but also on how changes within the ventricle may affect connected subarachnoid spaces and the route toward the spinal canal.
Its location places cerebrospinal fluid circulation close to the brainstem and cerebellum, making it relevant to studies of immune activity in the central nervous system. Researchers can use this anatomical context to examine how inflammatory mediators, pathogen-associated effects, and altered fluid pathways contribute to neurological complications during infection.