Acute Lung Re-ventilation
Acute Lung Re-ventilation - Related Videos
07:55
Pressure Controlled Ventilation to Induce Acute Lung Injury in Mice
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Cited by 7 •
2011
A murine model for ventilator induced lung injury is an important tool to study an acute lung injury in vivo. Here, we report an easy applicable in situ model for acute lung injury using high-pressure mechanical ventilation to induce acute failure of the lung.
08:58
Development of a Neonatal Piglet Acute Lung Injury Model Recreating the Early Environment of Preterm Infant Lungs
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2025
This protocol describes the development of a neonatal piglet model of acute lung injury that models early pathogenic events occurring in the preterm lung, including sub-adequate surfactant quantity, hyperoxia, high-pressure ventilation, and inflammation, to facilitate understanding of molecular triggers of bronchopulmonary dysplasia and enhance therapeutic translation.
10:02
Characterization of the Isolated, Ventilated, and Instrumented Mouse Lung Perfused with Pulsatile Flow
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Cited by 12 •
2011
The following protocol outlines the process of isolating, ventilating and instrumenting mouse lungs to measure steady or pulsatile pulmonary vascular pressure-flow relationships in order to quantify the effects of blood flow, airflow, airway changes and vascular changes on right ventricular afterload.
04:10
Non-Invasive Endotracheal Administration of Lipopolysaccharide to Induce Acute Lung Injury in Rodents
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2025
In this study, a non-invasive endotracheal instillation technique is demonstrated to develop ALI in rats using a basic laryngoscope to ensure precise LPS delivery to the lungs. The LPS is instilled via an endotracheal tube using a laryngoscope. The magnitude of lung injury is evaluated at multiple time points.
05:56
Phase-Resolved Functional Lung MRI for Pulmonary Ventilation and Perfusion (V/Q) Assessment
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Cited by 8 •
2024
Here, we describe the implementation of phase-resolved functional lung MRI as a contrast-agent-free proton MR technique for the assessment of pulmonary ventilation and perfusion dynamics. Validated and applicable across different field strengths and age groups, it could enhance clinical decision-making in the future by aiding in disease quantification and therapy monitoring.
FAQs
The key pressure sequence is an inspiratory increase followed by appropriate positive end-expiratory pressure, or PEEP. The higher inspiratory pressure helps reopen affected alveoli, while PEEP supports their continued patency after expiration. This matters because reopening without maintaining end-expiratory support may not sustain improved ventilation or gas exchange in the previously collapsed region.
The response should be judged across oxygenation, ventilation, and hemodynamic status. Improvement in oxygenation can indicate better gas exchange, but clinicians must also assess ventilation and circulatory effects. Considering all three responses helps distinguish useful recruitment from pressure-related deterioration and supports safer adjustment during acute care.
Pressure must be increased carefully because reopening lung regions is not the only goal. Excessive airway pressure can impair circulation and may contribute to ventilator-induced lung injury. The practical objective is therefore a balance: achieve improved regional aeration while avoiding pressure levels that worsen hemodynamic responses or lung damage.
A typical clinical approach begins with controlled increases in inspiratory airway pressure. Clinicians then apply appropriate PEEP and reassess oxygenation, ventilation, and hemodynamic responses. Further adjustment depends on those monitored effects, with the aim of reopening affected regions and preserving alveolar patency without excessive pressure.
Acute lung re-ventilation may be considered when regional collapse follows anesthesia, one-lung ventilation, airway obstruction, or another acute cause. The triggering situation helps clinicians identify why airflow has been reduced and whether restoring ventilation could address associated hypoxemia or atelectasis in the affected region during acute care when appropriate.
Successful treatment is not defined solely by opening collapsed tissue. Clinicians look for improved oxygenation and ventilation while checking that hemodynamic status remains acceptable. If gas exchange does not improve, or circulatory effects worsen, the pressure strategy may require reassessment rather than continued escalation alone.