Brain Mri

Brain MRI is a noninvasive imaging technique that uses magnetic fields and radio waves to produce detailed pictures of the brain and surrounding structures, without ionizing radiation. In a strong magnetic field, hydrogen protons in body tissues align; radiofrequency pulses disturb this alignment, and the signals released as protons return to equilibrium are processed into images with different tissue contrasts. Brain MRI can reveal tumors, stroke-related changes, inflammation, bleeding, vascular abnormalities, and structural differences, while functional and diffusion-based sequences provide additional information about brain activity and tissue organization. Clinicians and researchers use it to support diagnosis, treatment planning, disease monitoring, and investigations of neurological function.

Brain Mri - Related Videos

Research

JoVE Journal - Neuroscience
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Utilizing 3D Printing Technology to Merge MRI with Histology: A Protocol for Brain Sectioning

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Cited by 33 •

2016

The overall goal of this protocol is to accurately align magnetic resonance imaging (MRI) image volumes with histology sections via the creation of customized 3D-printed brain holders and slicer boxes.

Research

JoVE Journal - Neuroscience

Functional Neuroimaging Using Ultrasonic Blood-brain Barrier Disruption and Manganese-enhanced MRI

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Cited by 4 •

2012

A technique is described for broadly opening the blood-brain barrier in the mouse using microbubbles and ultrasound. Using this technique, manganese can be administered to the mouse brain. Because manganese is an MRI contrast agent that accumulates in depolarized neurons, this approach enables imaging of neuronal activity.

MRI-guided Disruption of the Blood-brain Barrier using Transcranial Focused Ultrasound in a Rat Model

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Cited by 18 •

2012

Microbubble-mediated focused ultrasound disruption of the blood-brain barrier (BBB) is a promising technique for non-invasive targeted drug delivery in the brain1-3. This protocol outlines the experimental procedure for MRI-guided transcranial BBB disruption in a rat model.

Research

JoVE Journal - Neuroscience
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Optogenetic Functional MRI

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Cited by 15 •

2016

This protocol describes the steps and data analysis required to successfully perform optogenetic functional magnetic resonance imaging (ofMRI). ofMRI is a novel technique that combines high-field fMRI readout with optogenetic stimulation, allowing for cell type-specific mapping of functional neural circuits and their dynamics across the whole living brain.

MRI-guided dmPFC-rTMS as a Treatment for Treatment-resistant Major Depressive Disorder

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Cited by 31 •

2015

Here we outline the procedure for MRI-guided repetitive transcranial magnetic stimulation to the dorsomedial prefrontal cortex as an experimental treatment for major depressive disorder.

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