Fibrous Ring Puncture

Fibrous ring puncture is a medical procedure that penetrates the annulus fibrosus, the tough outer ring surrounding an intervertebral disc, to access the disc space for diagnostic or therapeutic purposes. Under imaging guidance, a needle passes through the annular fibers into the nucleus pulposus, allowing clinicians to inject contrast medium, obtain tissue or fluid samples, or deliver treatment while monitoring needle position and disc responses. The technique is most closely associated with discography and selected intradiscal interventions, helping evaluate suspected discogenic pain, characterize structural damage, and guide clinical decisions. Because the procedure can stress or injure disc tissue, careful patient selection and sterile technique are essential.

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Education

JoVE Core - Molecular Biology

Globular and Fibrous Proteins

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2020

Many proteins can be classified into two distinct subtypes - globular or fibrous. These two types differ in their shapes and solubilities. Globular proteins are also known as spheroproteins and typically are approximately round in shape. They contain a mix of amino acid types and contain differing sequences in their primary structures. Globular proteins have many different functions, such as enzymes, cellular messengers, and molecular transporters. These roles often require the proteins to be...

Fibrous Proteins

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2023

Fibrous proteins are either long and narrow proteins or assemble to form long and thin structures. They contain repetitive units and usually consist of either alpha helices or beta sheets and, in rare cases, a mix of both. The amino acids in the primary structure often consist of repeating amino acid sequences. The role of fibrous proteins is primarily structural. Many are located in the extracellular matrix and are present in connective tissues to impart strength and joint mobility. They are...

Research

JoVE Journal - Medicine

Cecal Ligation Puncture Procedure

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Cited by 200 •

2011

The mouse model of cecal ligation and puncture as a valuable tool for the study of human sepsis.

Structural Joints: Fibrous Joints

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2025

Fibrous joints are a type of joint where the bones are connected by fibrous connective tissue. These joints provide stability and minimal to no movement between the articulating bones. There are three types of fibrous joints. Suture All the bones of the skull, except for the mandible, are joined to each other by a fibrous joint called a suture. The fibrous connective tissue found at a suture strongly unites the adjacent skull bones and thus helps to protect the brain and form the face. In...

Research

JoVE Journal - Bioengineering
Free Sample

In vitro Synthesis of Native, Fibrous Long Spacing and Segmental Long Spacing Collagen

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Cited by 16 •

2012

Simple and reproducible procedures are described for making three structurally distinct collagen assemblies from a common commercially available Type I collagen monomer. Native type, fibrous long spacing or segmental long spacing collagen can be constructed by varying the conditions to which the 300 nm long and 1.4 nm diameter monomer building block is exposed.

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