Retinal Vascular Diseases
Retinal Vascular Diseases - Related Videos
07:22
Quantitative Fundus Autofluorescence for the Evaluation of Retinal Diseases
0 Views •
Cited by 22 •
2016
The retinal pigment epithelium (RPE) supports the sensory retina through recycling visual cycle byproducts, which accumulate as lipofuscin. These products are autofluorescent and can be qualitatively imaged in vivo. Here, we describe a method to quantitatively image RPE lipofuscin using confocal scanning laser ophthalmoscopy.
08:50
Assessment of Vascular Function in Patients With Chronic Kidney Disease
0 Views •
Cited by 25 •
2014
The degree of vascular dysfunction and contributing physiological mechanisms can be assessed in patients with chronic kidney disease by measuring brachial artery flow-mediated dilation, aortic pulse-wave velocity, and vascular endothelial cell protein expression.
10:14
Using Adeno-associated Virus as a Tool to Study Retinal Barriers in Disease
0 Views •
Cited by 6 •
2015
To investigate the blood-retinal barrier permeability and the inner limiting membrane integrity in animal models of retinal disease, we used several adeno-associated virus (AAV) variants as tools to label retinal neurons and glia. Virus mediated reporter gene expression is then used as an indicator of retinal barrier permeability.
09:06
Orthotopic Aortic Transplantation in Mice for the Study of Vascular Disease
0 Views •
Cited by 7 •
2012
We describe a technique in which a section of the abdominal aorta from a mouse is transplanted orthotopically to just below the renal arteries in an allogeneic or syngeneic recipient. This technique can be useful in studies in which transplantation of large arteries of uniform size is deemed advantageous.
09:17
Using Retinal Imaging to Study Dementia
0 Views •
Cited by 19 •
2017
The retina shares prominent similarities with the brain and thus represents a unique window to study vasculature and neuronal structure in the brain non-invasively. This protocol describes a method to study dementia using retinal imaging techniques. This method can potentially aid in diagnosis and risk assessment of dementia.
FAQs
Reduced retinal blood flow produces ischemia, meaning inadequate oxygen delivery to retinal tissue. Damaged or overly permeable vessels can then allow fluid or blood to accumulate, disrupting retinal structure and vision. In some cases, pathological neovascularization develops as an abnormal vascular response. These processes may occur together, so evaluation must consider both circulation and tissue changes rather than a single abnormality.
Diabetic retinopathy and retinal artery or vein occlusion arise from different vascular patterns, yet each can disturb retinal function through ischemia, hemorrhage, leakage, or tissue swelling. A narrowed or blocked vessel primarily compromises circulation, while vessel damage may increase permeability. Because these effects overlap, clinical assessment relies on observed structural and circulatory findings to distinguish the underlying disorder.
The retinal circulation can reflect broader vascular problems because retinal vessels may be affected by systemic risk factors and circulatory injury. Consequently, an abnormal retinal finding has significance beyond vision: it can support attention to overall vascular health while guiding eye-specific evaluation. This connection makes retinal vascular disease relevant to both ophthalmic care and wider medical assessment.
These approaches provide complementary information. Fundus examination directly assesses visible retinal and vascular features, including hemorrhagic or abnormal changes. Optical coherence tomography, commonly abbreviated OCT, reveals retinal structure and fluid-related changes. Vascular imaging adds information about circulation and vessel abnormalities. Together, the tests help identify the structural and circulatory consequences that shape diagnosis and management.
Findings from retinal examination and imaging help determine whether vision is threatened by edema, abnormal vessel growth, ischemic injury, or other vascular consequences. Management may combine control of systemic risk factors with therapies directed at reducing retinal edema or pathological neovascularization. Linking treatment to the dominant mechanism supports vision preservation while allowing clinicians to monitor structural and circulatory outcomes.
They are important when researchers or clinicians need to connect retinal changes with mechanisms of diabetes, vascular obstruction, or broader cardiovascular health. Imaging can document disease-related alterations and help assess responses to therapies that reduce edema or abnormal vessel growth. This makes retinal vascular disease a useful context for studying vision preservation alongside relationships between retinal and systemic vascular disorders.