Asymmetric Cell Division
Asymmetric Cell Division - Related Videos
05:44
Cell Division - Concepts
0 Views •
2019
Cell division is fundamental to all living organisms and required for growth and development. As an essential means of reproduction for all living things, cell division allows organisms to transfer their genetic material to their offspring. For a unicellular organism, cellular division generates a completely new organism. For multicellular organisms, cellular division produces new cells for the general development of the organism, as well as produces healthy cells to replace damaged cells from...
06:20
Cell Division - Student Protocol
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2019
Observing the Cell Cycle in a Root Tip ExpandHypotheses: The experimental hypothesis is that in root tips slices that have been treated with nocodazole, a chemical that interferes with microtubular polymerization, all of the cells will be arrested at the same stage of the cell cycle and that in untreated onion tip slices all of the different stages of the cell cycle will be visualized. The null hypothesis is that there will be no differences in mitosis between the two groups and that different...
00:53
Cell Division - Instructor Prep
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2019
Preparation of Onion Root Tips and Solutions ExpandFor the cell cycle experiment using root tips, first, leave an onion suspended over a beaker of water to grow roots for several days. Then, clean the onion roots of any dirt or debris. Next, in a 1.5 mL tube, dissolve 10 mcg of nocodazole per 1 mL of dimethyl sulfoxide solution, making 1 tube per student. Finally, set out all of the other tools, materials, and reagents from the list of materials onto each student's lab bench.
10:03
An Introduction to Cell Division
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2023
Cell division is the process by which a parent cell divides and gives rise to two or more daughter cells. It is a means of reproduction for single-cell organisms. In multicellular organisms, cell division contributes to growth, development, repair, and the generation of reproductive cells (sperms and eggs). Cell division is a tightly regulated process, and aberrant cell division can cause diseases, notably cancer. JoVE's Introduction to Cell Division will cover a brief history of the landmark...
04:24
Studying Cell Rolling Trajectories on Asymmetric Receptor Patterns
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Cited by 3 •
2011
We describe a protocol to observe and analyze cell rolling trajectories on asymmetric receptor-patterned substrates. The resulting data are useful for engineering of receptor-patterned substrates for label-free cell separation and analysis.
FAQs
Cell polarity establishes an internal organization that positions cellular components, while spindle orientation determines how the parent cell divides relative to that organization. Together, they help direct unequal inheritance during division. Their coordinated action allows the two daughter cells to receive different developmental instructions, linking the physical geometry of division to distinct outcomes in neural development.
Unequal segregation gives daughter cells different starting contents after division. Fate-determining proteins can activate distinct molecular programs, while inherited organelles may contribute to functional differences between the daughters. This unequal distribution helps neural stem and progenitor cells produce one cell that retains stem-like capacity and another that moves toward a neuronal or glial fate.
The relative sizes of daughter cells, the contents they inherit, and their developmental fates all influence neural development. Because these outcomes determine whether daughters continue self-renewal or generate neurons and glial cells, division asymmetry affects both the number of developing cells and the range of cell types produced. These effects contribute to nervous-system architecture and diversity.
Examining polarity, spindle orientation, and unequal molecular inheritance connects cellular events with larger developmental outcomes. Researchers can use these relationships to understand how neural stem and progenitor cells generate appropriately different descendants while maintaining tissue organization. The resulting insights help explain how local division patterns contribute to the architecture and overall cellular diversity of the nervous system.
This process provides a framework for studying how neural stem and progenitor cells balance self-renewal with differentiation. Self-renewal preserves a continuing source of cells, whereas production of neurons and glia expands the developing neural population into specialized lineages. Investigating this balance helps explain how stem-cell behavior contributes to normal neural development and tissue formation.
Research on this process informs neural repair by identifying how stem and progenitor cells generate different descendants and maintain developmental potential. It also helps connect disrupted division mechanisms with abnormal brain formation and neurological disease. Understanding these relationships provides scientific context for evaluating stem-cell behavior and for investigating how developmental errors may affect nervous-system structure.