Baseline Imaging
Baseline Imaging - Related Videos
09:52
Non-invasive Optical Imaging of the Lymphatic Vasculature of a Mouse
0 Views •
Cited by 25 •
2013
Recently developed imaging techniques using near-infrared fluorescence (NIRF) may help elucidate the role the lymphatic system plays in cancer metastasis, immune response, wound repair, and other lymphatic-associated diseases.
09:24
Molecular Imaging to Target Transplanted Muscle Progenitor Cells
0 Views •
Cited by 3 •
2013
A non-invasive means to evaluate the success of myoblast transplantation is described. The method takes advantage of a unified fusion reporter gene composed of genes whose expression can be imaged with different imaging modalities. Here, we make use of a fluc reporter gene sequence to target cells via bioluminescence imaging.
13:45
Hybrid µCT-FMT imaging and image analysis
0 Views •
Cited by 34 •
2015
We describe a protocol for hybrid imaging, combining fluorescence-mediated tomography (FMT) with micro computed tomography (µCT). After fusion and reconstruction, we perform interactive organ segmentation to extract quantitative measurements of the fluorescence distribution.
13:05
Functional Magnetic Resonance Imaging (fMRI) with Auditory Stimulation in Songbirds
0 Views •
Cited by 12 •
2013
This article shows an optimized procedure for imaging of the neural substrates of auditory stimulation in the songbird brain using functional Magnetic Resonance Imaging (fMRI). It describes the preparation of the sound stimuli, the positioning of the subject and the acquisition and subsequent analysis of the fMRI data.
09:43
In vivo Near Infrared Fluorescence (NIRF) Intravascular Molecular Imaging of Inflammatory Plaque, a Multimodal Approach to Imaging of Atherosclerosis
0 Views •
Cited by 32 •
2011
We detail a new near-infrared fluorescence (NIRF) catheter for 2-dimensional intravascular molecular imaging of plaque biology in vivo. The NIRF catheter can visualize key biological processes such as inflammation by reporting on the presence of plaque-avid activatable and targeted NIR fluorochromes. The catheter utilizes clinical engineering and power requirements and is targeted for application in human coronary arteries. The following research study describes a multimodal imaging strategy...
FAQs
Standardized conditions make the initial measurements more comparable with images collected later. If acquisition circumstances vary substantially, observed differences may reflect measurement conditions rather than biological change. Consistent baseline procedures therefore strengthen comparisons across time and help researchers interpret changes in brain structure or physiological signals with greater confidence.
The initial dataset provides an individual or experimental reference against which subsequent measurements can be evaluated. Researchers can then determine whether later differences exceed the variation already present at the starting point. This comparison improves interpretation of developmental, pathological, or treatment-related changes by reducing the risk of attributing ordinary variability to an intervention or disease process.
The selected modality determines which features are represented in the reference dataset. Magnetic resonance imaging can contribute anatomical information, whereas positron emission tomography and optical imaging can capture physiological signals. Using the modality that matches the research question allows later comparisons to focus on structural features, functional activity, or both when the study design supports that approach.
Researchers acquire it before an intervention, experiment, or disease-related change that they intend to evaluate. Establishing the reference before these events is essential because later images can then be interpreted relative to the pre-existing state. The timing also supports longitudinal designs in which repeated measurements track development, injury, disease progression, or treatment response.
In a longitudinal study, the baseline dataset serves as the starting point for comparing images acquired at later stages. This framework allows researchers to follow changes within the same investigation over time rather than relying only on separate measurements. It is particularly useful for examining brain development, injury, disease progression, and responses to treatment.
Baseline Imaging can support studies asking whether brain structure or physiological activity changes after an intervention, during disease progression, following injury, or across development. It also helps evaluate treatment response by providing a pre-treatment reference. These applications connect image-based measurements to neural outcomes and improve the precision of conclusions drawn from repeated observations.