Closed-head Injury Model
Closed-head Injury Model - Related Videos
03:01
Generating a Closed-Head Mild Traumatic Brain Injury in a Murine Model
0 Views •
2025
Source: Logsdon, A. F., et al. Low-intensity Blast Wave Model for Preclinical Assessment of Closed-head Mild Traumatic Brain Injury in Rodents. J. Vis. Exp. (2020)This video demonstrates the induction of closed-head mild traumatic brain injury in a mouse model using a pressurized gas shock tube setup. The generated pressure wave ruptures the polyester membrane, delivering a shockwave to the mouse’s head that results in rapid brain movement within the skull, causing a mild traumatic brain injury.
02:48
A Method to Inflict Closed Head Traumatic Brain Injury in Drosophila
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2025
The video demonstrates the use of a High-Impact Trauma (HIT) device to induce closed-head traumatic brain injury (TBI) in Drosophila. TBI causes mechanical brain trauma affecting neuronal function, which over time leads to neurodegeneration and mortality.
05:22
A Method to Inflict Closed Head Traumatic Brain Injury in Drosophila
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Cited by 37 •
2015
Here we describe a method to inflict closed head traumatic brain injury (TBI) in Drosophila. This method provides a gateway to investigate the cellular and molecular mechanisms that underlie TBI pathologies using the vast array of experimental tools and techniques available for flies.
03:19
A Technique to Inflict Closed-Head Traumatic Brain Injury in Drosophila Flies
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2025
This video demonstrates a procedure to inflict a closed-head traumatic injury in anesthetized Drosophila flies using a strike device with a gas-propelled impactor. The injury affects neuronal function and impairs walking ability.
09:07
Electromagnetic Controlled Closed-Head Model of Mild Traumatic Brain Injury in Mice
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Cited by 9 •
2022
The protocol describes mild traumatic brain injury in a mouse model. In particular, a step-by-step protocol to induce a mild midline closed head injury and the characterization of the animal model is fully explained.
FAQs
The intact skull does not block injury; it transmits impact energy to underlying tissues. Resulting deformation creates strain within the brain, which can disrupt axons, alter blood vessels, and change neuronal function. This combination allows the model to connect a physical impact with cellular and functional consequences that may evolve after the event.
Damage is not limited to the moment of impact. Axonal disruption, vascular changes, neuroinflammation, and altered neuronal function can emerge or progress over time. Following these processes at different stages helps distinguish immediate effects from later consequences, making time course an important part of interpreting injury severity, recovery, and potential treatment responses.
Its defining experimental advantage is that force is delivered while the skull remains intact, so researchers can study trauma without directly exposing brain tissue. That distinction is relevant when interpreting results, because observed damage can be related to energy transfer through the skull rather than to surgical exposure itself.
A study first applies a controlled mechanical force to the intact skull, then examines the resulting neurological consequences under controlled experimental conditions. Researchers can assess acute changes and follow later cognitive, motor, or behavioral outcomes, while also investigating tissue, vascular, inflammatory, neuronal, or biomarker changes associated with the injury.
The model can link structural and cellular changes to functional consequences, including cognitive, motor, and behavioral deficits. It also supports examination of biomarkers and recovery processes, allowing investigators to compare biological signals with observable neurological outcomes. These combined measurements help characterize both the extent of injury and how its effects develop over time.
Because the model produces injury under controlled experimental conditions, researchers can examine how brain changes and neurological deficits evolve during recovery. They can also use the system to investigate potential treatments alongside biomarkers and functional outcomes. In neuroscience, this supports evaluation of whether an intervention relates to improved recovery or altered injury-associated processes.