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TOPICAL COLLECTIONS

Brain Trauma Models: Current Methods in Experimentation, Screening and Treatment of Traumatic Brain Injury

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Guest Editors

Lili-Naz Hazrati

Lili-Naz Hazrati

The Hospital for Sick Children, Department of Paediatric Laboratory Medicine; University of Toronto, Department of Laboratory Medicine and Pathobiology

Dr. Lili-Naz Hazrati MD, PhD, FRCPC is a staff neuropathologist at the Hospital for Sick Children, clinician scientist at the SickKids Research Institute, and an Associate Professor at the University of Toronto. She completed her PhD in neurobiology at Laval University followed by postdoctoral training at Yale University. She obtained her medical degree at the University of Montreal and residency training in neuropathology at the University of Toronto. Currently, Dr. Hazrati and her lab investigate molecular mechanisms underlying neurodegeneration induced by brain trauma. The team aims to elucidate key molecular players that drive chronic physiological and behavioral changes post-TBI. Their recent findings have brought forward DNA damage-induced cellular senescence as a significant contributor to TBI-associated brain dysfunction. Additionally, Dr. Hazrati and her team examine patient brain banks for a systematic approach to identifying potential treatment strategies.

Daria Taskina

Daria Taskina

The Hospital for Sick Children, Department of Pediatric Laboratory Medicine

Daria Taskina is a research associate in Dr. Hazrati’s laboratory at the Hospital for Sick Children, Toronto, Canada. She is currently investigating neuroinflammatory and chronic behavioral outcomes of brain trauma. In her recent graduate research with Dr. Georg R. Zoidl at York University, Daria examined the role of Pannexin1 channels in the onset and propagation of seizures in a zebrafish model. Her areas of expertise include molecular and behavioral assessment of neurological disorders in animal models, in-vivo electrophysiology, and implementing computational analyses such as machine learning techniques into her research.

Collection Overview

Traumatic brain injury (TBI) remains a leading cause of mortality and long-term neurological disability worldwide, yet translational progress in diagnosis, therapeutic development, and neurorehabilitation has been hindered by the complexity and heterogeneity of brain trauma. Experimental brain trauma models—ranging from in vitro systems and organoids to rodent and large-animal models—have become indispensable for elucidating injury mechanisms, biomarker discovery, and preclinical therapeutic screening.


Despite substantial methodological evolution, the field faces persistent challenges, including limited model reproducibility, variability in injury severity paradigms, inadequate representation of chronic and mild TBI, and gaps in translating preclinical findings into effective clinical interventions. Additionally, standardization of experimental protocols, integration of multimodal imaging and omics approaches, and validation of therapeutic screening platforms remain critical unmet needs.


This Collection aims to provide a multidisciplinary platform that integrates method articles, original research articles, and reviews addressing experimental protocols, mechanistic insights, therapeutic screening strategies, and emerging treatment modalities.


By compiling diverse studies, this collection will serve as a valuable resource for neuroscientists, clinicians, bioengineers, and translational researchers. It will foster methodological harmonization, accelerate therapeutic discovery, and enhance the scientific community’s ability to design

Articles

Low-intensity Blast Wave Model for Preclinical Assessment of Closed-head Mild Traumatic Brain Injury in Rodents
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Low-intensity Blast Wave Model for Preclinical Assessment of Closed-head Mild Traumatic Brain Injury in Rodents

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Cited by 8

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2020

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Abstracts

Traumatic brain injury: an experimental model

Fernando Zanela da Silva Areas*1

1Laboratory of Neurorehabilitation and Neuromodulation, Univerisdade Federal do Espírito Santo