Controlled Delivery
Controlled Delivery - Related Videos
15:04
Modeling and Simulations of Olfactory Drug Delivery with Passive and Active Controls of Nasally Inhaled Pharmaceutical Aerosols
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Cited by 18 •
2016
This manuscript reviews the modeling and simulations of different protocols to deliver medications to the olfactory region in image-based nasal airway models. Multiple software modules are used to develop the anatomically accurate nose model, generate computational mesh, simulate nasal airflows, and predict particle deposition at the olfactory region.
08:02
Cell Squeezing as a Robust, Microfluidic Intracellular Delivery Platform
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Cited by 40 •
2013
Rapid mechanical deformation of cells has emerged as a promising, vector-free method for intracellular delivery of macromolecules and nanomaterials. This protocol provides detailed steps on how to use the system for a broad range of applications.
05:00
Ex Vivo Culture of Patient Tissue & Examination of Gene Delivery
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Cited by 4 •
2010
This article describes the culture of patient tissue slices for gene delivery studies and subsequent analysis of gene expression using IVIS bioluminescence imaging.
06:30
Intraductal Delivery to the Rabbit Mammary Gland
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Cited by 9 •
2017
Here, we describe a technique for the localized delivery of reagents to the rabbit mammary gland via an intraductal injection. In addition, we describe a protocol for visualization and the confirmation of delivery by high-resolution ultrasound imaging of contrast agents.
02:58
Convection-Enhanced Delivery of Antibodies into a Mouse Brain
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2025
This video demonstrates a convection-enhanced delivery (CED) technique for antibody delivery into the mouse brain. The skull of an anesthetized mouse is exposed, and a burr hole is created at the target area for antibody delivery. A step catheter containing antibodies is inserted at the target site, and via an infusion pump, a pressure gradient is created to deliver antibodies at a controlled rate.
FAQs
These mechanisms regulate transport through different material or structural features. Diffusion controls movement from a carrier, matrix degradation changes release as the carrier breaks down, encapsulation surrounds the therapeutic substance, and stimulus-responsive materials alter transport in response to relevant conditions. Selecting among them helps align delivery with a desired rate, duration, or location.
Biological barriers can limit how substances reach the brain, spinal cord, or nearby neural tissue. A delivery strategy must therefore address transport across those barriers while preserving useful concentrations at the intended site. Managing this relationship can improve local exposure and reduce the amount reaching healthy tissue elsewhere in the body.
Stimulus-responsive materials provide a way to regulate transport according to conditions associated with the delivery environment. In neuroscience, this approach can help control when or where a substance becomes available near neural tissue. Its value lies in connecting material behavior with targeted exposure rather than relying only on unrestricted distribution.
The design should match the intended release rate, timing, and anatomical location of the therapy. A carrier or device may be selected to support diffusion, degradation, encapsulation, or stimulus-responsive transport, depending on the desired outcome. These choices influence whether concentrations remain near neural tissue and whether administration can be sustained.
Planning begins by identifying where the substance should act, how long useful exposure should continue, and how precisely release must be regulated. Researchers can then relate those goals to a carrier or device and a transport mechanism such as diffusion or matrix degradation. This framework helps connect material selection with neural targeting and dosing needs.
It is especially relevant when therapy must reach neural tissue while limiting exposure to healthy tissue, or when repeated dosing is difficult. Regulated release can help maintain local concentrations and support sustained administration. These features make the approach useful for developing treatments aimed at disorders affecting the brain or spinal cord.
Researchers can examine whether a substance reaches the intended neural location, whether local concentrations are maintained, and whether exposure to healthy tissue is reduced. They can also assess whether administration remains sustained when repeated dosing presents a challenge. Together, these outcomes connect delivery performance with the potential effects of neural interventions.